Comparative Assessment of the Therapeutic Efficacy of Selected Pashanbheda Plants

Background

The process of formation or appearance of a urinary stone anywhere in the renal tract is known as urolithiasis. Several plants are used and sold as ‘Pashanbheda' in different parts of the world. In this work we have selected three medicinal plants which are considered as Pashanbhed. The plants were Bergenia ligulata, Bergenia ciliata, and Aerva lanata each with unique phytochemical profiles and therapeutic benefits.

Objectives

The present work aims to analysis of these three species and evaluate the antiurolithiatic potential of these plants. This approach will provide an insight to find which plant exhibit maximum antiurolithiatic potential.

Materials and Methods

To achieve this methanolic extract of plant was prepared. Antioxidant activity estimated by monitoring DPPH assay. Phytochemical profiling, Phenolic and flavonoid content also be estimated to monitor the antioxidant potential of these plants. The qualitative and quantitative estimation of phytochemical constituents carried out by HPLC analysis.

Results

By comparing the results of phytochemical estimation, DPPH assay, TPC determination, TFC estimation and HPLC analysis our study shows that out of these three plants Bergenia ligulata considered to possess maximum antiurolithiatic potential.

Conclusion

This work provides a comparative evaluation of three medicinal plants Bergenia ligulata, Bergenia ciliata, and Aerva lanata all traditionally referred to as Pashanbheda, despite significant taxonomical and phytochemical differences. Unlike previous studies that examine these plants individually, this study offers a systematic, side-by-side assessment of their antioxidant activity, phytochemical content, and antiurolithiatic potential using standardized methodologies. The study integrates DPPH-based antioxidant assays, total phenolic and flavonoid quantification, and HPLC profiling, providing a more comprehensive approach for determining the most potent antiurolithiatic species. It highlights Bergenia ligulata as the species with maximum antiurolithiatic potential.