Open access · Peer reviewed · No APCs
Original ArticlePharmacognosy ResearchVol. 2 | Issue 1 | 2010 | pp. 10–14Open access
Solanum trilobatum in the management of atopy: Through inhibition of mast cell degranulation and moderation of release of interleukins
- 1*,
- 3,
- 1,
- 4,
- 2,
- 5,
- 1
- 1 Faculty of Medicine, Microbiology Unit
- 2 Anatomy Unit, AIMST University, Kedah, Malaysia
- 3 Department of Advanced Zoology and Biotechnology, Sri Paramakalyani College, Alwarkurichi
- 4 Sri Paramakalyani Center for Environmental Sciences, M. S. University, Tirunelveli
- 5 R and D Center, Cholayil Private Limited, Chennai, India
Published in Pharmacognosy Research
Correspondence: M. S. Ranjith
Faculty of Medicine, Microbiology Unit
Email: msranjith@yahoo.com
Copyright: © 2010 Manuscript Technomedia. This is an open access article.
- Published:
- Jan 1, 2010
- Received:
- Oct 5, 2009
- Accepted:
- Mar 13, 2010
How to cite
Ranjith, M. S., Ranjitsingh, A. J. A., Shankar, S. G., Vijayalaksmi, G. S., Deepa, K., Babu, K., & Sidhu, H. S. (2010). Solanum trilobatum in the management of atopy: Through inhibition of mast cell degranulation and moderation of release of interleukins. Pharmacognosy Research, 2(1), 10–14. https://doi.org/10.4103/0974-8490.60581
Abstract
Solanum trilobatum is a widely used plant in the Indian indigenous systems of medicine. It is mainly used in the treatment of respiratory diseases like bronchial asthma. In our present study, we report that the aqueous and alcoholic extracts of S. trilobatum exhibited inhibition of mast cell degranulation. Further, aqueous and alcoholic extracts of S. trilobatum significantly decreased the release of IL1a and increased the release of IL8 from the cultured keratinocytes. Oral administration of the aqueous and alcoholic extracts of S. trilobatum stabilized mast cells in experimental rats.
Keywords
Subject
Article metadata
| Title | Solanum trilobatum in the management of atopy: Through inhibition of mast cell degranulation and moderation of release of interleukins |
|---|---|
| Authors | M. S. Ranjith; A. J. A. Ranjitsingh; S. Gokul Shankar; G. S. Vijayalaksmi; K. Deepa; K. Babu; Harcharan Singh Sidhu |
| Affiliations | Faculty of Medicine, Microbiology Unit; Anatomy Unit, AIMST University, Kedah, Malaysia; Department of Advanced Zoology and Biotechnology, Sri Paramakalyani College, Alwarkurichi; Sri Paramakalyani Center for Environmental Sciences, M. S. University, Tirunelveli; R and D Center, Cholayil Private Limited, Chennai, India |
| Corresponding author | msranjith@yahoo.com |
| Journal | Pharmacognosy Research |
| Volume / Issue | Vol. 2, Issue 1 (2010) |
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