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EditorialPharmacognosy ResearchVol. 3 | Issue 2 | 2011 | pp. 107–113Open access
Screening for estrogenic and antiestrogenic activities of plants growing in Egypt and Thailand
- 1,2,
- 1,2,
- 1,
- 3,
- 1*
- 1 Department of Metabolic Engineering, Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama 930-0194
- 2 Department of Pharmacognosy, Faculty of Pharmacy, Cairo University 11562
- 3 Faculty of Pharmaceutical Sciences, Hyogo College of Medicine, 1-3-6 Minatojima, Chuo-Ku, Kobe 650-0045, Japan
Published in Pharmacognosy Research
Correspondence: Masao Hattori
Department of Metabolic Engineering, Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama 930-0194
Email: saibo421@inm.u-toyama.ac.jp
Copyright: © 2011 Manuscript Technomedia. This is an open access article.
- Published:
- Jan 1, 2011
How to cite
El-Halawany, A. M., Dine, R. S. E., Chung, M. H., Nishihara, T., & Hattori, M. (2011). Screening for estrogenic and antiestrogenic activities of plants growing in Egypt and Thailand. Pharmacognosy Research, 3(2), 107–113. https://doi.org/10.4103/0974-8490.81958
Abstract
Background
There is a growing demand for the discovery of new phytoestrogens to be used as a safe and effective hormonal replacement therapy.
Materials and Methods
The methanol extracts of 40 plants from the Egyptian and Thailand folk medicines were screened for their estrogen agonist and antagonist activities. The estrogenic and antiestrogenic effects of the tested extracts were carried out using the yeast two-hybrid assay system expressing ERα and ERβ. In addition, all the extracts were subjected to a naringinase treatment and retested for their estrogenic activity.
Results
The methanol extracts of Derris reticulata and Dracaena lourieri showed the most potent estrogenic activity on both estrogen-receptor subtypes, while, the methanol extracts of Butea monosperma, Erythrina fusca, and Dalbergia candenatensis revealed significant estrogenic activity on ERβ only. Nigella sativa, Sophora japonica, Artabotrys harmandii, and Clitorea hanceana showed estrogenic effect only after naringinase treatment. The most potent antiestrogenic effect was revealed by Aframomum melegueta, Dalbergia candenatensis, Dracena loureiri, and Mansonia gagei.
Keywords
Subject
Article metadata
| Title | Screening for estrogenic and antiestrogenic activities of plants growing in Egypt and Thailand |
|---|---|
| Authors | Ali M. El-Halawany; Riham Salah El Dine; Mi Hwa Chung; Tsutomu Nishihara; Masao Hattori |
| Affiliations | Department of Metabolic Engineering, Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama 930-0194; Department of Pharmacognosy, Faculty of Pharmacy, Cairo University 11562; Faculty of Pharmaceutical Sciences, Hyogo College of Medicine, 1-3-6 Minatojima, Chuo-Ku, Kobe 650-0045, Japan |
| Corresponding author | saibo421@inm.u-toyama.ac.jp |
| Journal | Pharmacognosy Research |
| Volume / Issue | Vol. 3, Issue 2 (2011) |
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