Open access · Peer reviewed · No APCs
EditorialPharmacognosy ResearchVol. 4 | Issue 3 | 2012 | pp. 161–165Open access
Chemical composition, antibacterial and antifungal activities of essential oil from Cordia verbenacea DC leaves
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- 1 Department of Biological Chemistry, Molecular Bioprospection Post-graduation Program, Laboratory of Natural Products Research, Regional University of Cariri, Crato, CE, Brazil
- 2 Vice-Rectory of Research and Post-Graduation, University of Fortaleza, Fortaleza, CE, Brazil
Published in Pharmacognosy Research
Correspondence: Jose Galberto M. Costa
Department of Biological Chemistry, Molecular Bioprospection Post-graduation Program, Laboratory of Natural Products Research, Regional University of Cariri, Crato, CE, Brazil
Email: galberto.martins@gmail.com
Copyright: © 2012 Manuscript Technomedia. This is an open access article.
- Published:
- Jan 1, 2012
How to cite
Rodrigues, F. F. G., Oliveira, L. G. S., Rodrigues, F. F. G., Saraiva, M. E., Almeida, S. C. X., Cabral, M. E. S., Campos, A. R., & Costa, J. G. M. (2012). Chemical composition, antibacterial and antifungal activities of essential oil from Cordia verbenacea DC leaves. Pharmacognosy Research, 4(3), 161–165. https://doi.org/10.4103/0974-8490.99080
Abstract
Background
Cordia verbenacea is a Brazilian coastal shrub popularly known as “erva baleeira”. The essential oil from fresh leaves was obtained by hydrodistillation and analyzed by CG/MS. The main components were identified as b-caryophyllene (25.4%), bicyclogermacrene (11.3%), q-cadinene (9.%) and a-pinene (9.5%). In this study, the antimicrobial activity of Cordia verbenacea was evaluated.
Materials and Methods
The minimal inhibitory concentration (MIC) of the essential oil was obtained using the broth microdilution assay (from 512 to 8 μg/ml).
Results
The results showed that the essential oil presented fungistatic activity against Candida albicans and Candida krusei and antibacterial activity against Gram-positive strains (Staphylococcus aureus and Bacillus cereus) and against multiresistant Gram-negative (Escherichia coli 27), in all tests the MIC was 64 μg/ml. When the essential oil was associated to aminoglycosides (subinhibitory concentrations, MIC/8), a synergic and antagonic activity was verified. The synergic effect was observed to the amikacin association (MIC reduction from 256 mlto 64 μg/ml) in all strains tested.
Conclusion
The essential oil of Cordia verbenacea influences the activity of antibiotics and may be used as an adjuvant in antibiotic therapy against respiratory tract bacterial pathogens.
Keywords
Subject
Article metadata
| Title | Chemical composition, antibacterial and antifungal activities of essential oil from Cordia verbenacea DC leaves |
|---|---|
| Authors | Fabiola F. G. Rodrigues; Liana G. S. Oliveira; Fábio F. G. Rodrigues; Manuele E. Saraiva; Sheyla C. X. Almeida; Mario E. S. Cabral; Adriana R. Campos; Jose Galberto M. Costa |
| Affiliations | Department of Biological Chemistry, Molecular Bioprospection Post-graduation Program, Laboratory of Natural Products Research, Regional University of Cariri, Crato, CE, Brazil; Vice-Rectory of Research and Post-Graduation, University of Fortaleza, Fortaleza, CE, Brazil |
| Corresponding author | galberto.martins@gmail.com |
| Journal | Pharmacognosy Research |
| Volume / Issue | Vol. 4, Issue 3 (2012) |
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