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EditorialPharmacognosy ResearchVol. 5 | Issue 2 | 2013 | pp. 109–112Open access
The triterpenoid fraction from Trichosanthes dioica root exhibits in vitro antileishmanial effect against Leishmania donovani promastigotes
- 1*,
- 2,
- 3
- 1 Division of Pharmacognosy, Bengal School of Technology (A College of Pharmacy), Hooghly
- 2 Bengal Institute of Pharmaceutical Sciences, Nadia
- 3 Department of Pharmaceutical Technology, Jadavpur University, Kolkata, West Bengal, India
Published in Pharmacognosy Research
Correspondence: Sanjib Bhattacharya
Division of Pharmacognosy, Bengal School of Technology (A College of Pharmacy), Hooghly
Email: sakkwai@yahoo.com
Copyright: © 2013 Manuscript Technomedia. This is an open access article.
- Published:
- Jan 1, 2013
How to cite
Bhattacharya, S., Biswas, M., & Haldar, P. K. (2013). The triterpenoid fraction from Trichosanthes dioica root exhibits in vitro antileishmanial effect against Leishmania donovani promastigotes. Pharmacognosy Research, 5(2), 109–112. https://doi.org/10.4103/0974-8490.110540
Abstract
Background
Trichosanthes dioica Roxb. (Cucurbitaceae), called pointed gourd in English is a dioecious climber found wild throughout the plains of the Indian subcontinent and traditionally used in India for several medicinal purposes.
Objective
The present study was aimed at the evaluation of in vitro antileishmanial effect of triterpenoid fraction from T. dioica root (CETD).
Materials and Methods
The antileishmanial activity of CETD was evaluated against Leishmania donovani (strain MHOM/IN/83/AG83) promastigotes by in vitro promastigote cell toxicity assay by using MTT (3-(4,5-dimethylthiazol-2-yl)-2,5 diphenyltetrazolium bromide). Potassium antimonyl tartrate was used as reference.
Results
Here, CETD markedly inhibited the growth of L. donovani promastigotes in vitro in a concentration dependent manner and demonstrated IC50 value of 18.75 mg/ml. The reference drug potassium antimonyl tartrate exhibited IC50 of 7.52 mg/ml.
Conclusion
From the present study it can be inferred that the triterpenoid fraction of T. dioica root exhibited remarkable antileishmanial activity against Leishmania donovani promastigotes in vitro.
Keywords
Subject
Article metadata
| Title | The triterpenoid fraction from Trichosanthes dioica root exhibits in vitro antileishmanial effect against Leishmania donovani promastigotes |
|---|---|
| Authors | Sanjib Bhattacharya; Moulisha Biswas; Pallab K. Haldar |
| Affiliations | Division of Pharmacognosy, Bengal School of Technology (A College of Pharmacy), Hooghly; Bengal Institute of Pharmaceutical Sciences, Nadia; Department of Pharmaceutical Technology, Jadavpur University, Kolkata, West Bengal, India |
| Corresponding author | sakkwai@yahoo.com |
| Journal | Pharmacognosy Research |
| Volume / Issue | Vol. 5, Issue 2 (2013) |
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