Open access · Peer reviewed · No APCs
EditorialPharmacognosy ResearchVol. 5 | Issue 4 | 2013 | pp. 306–308Open access
Mast cell stabilization potential of Sitopaladi churna: An ayurvedic formulation
- 1,
- 1,
- 1*
- 1 Department of Pharmacognosy, Manipal College of Pharmaceutical Sciences, Manipal University, Karnataka, India
Published in Pharmacognosy Research
Correspondence: H. N. Aswatha Ram
Department of Pharmacognosy, Manipal College of Pharmaceutical Sciences, Manipal University, Karnataka, India
Email: aswatharam@gmail.com
Copyright: © 2013 Manuscript Technomedia. This is an open access article.
- Published:
- Jan 1, 2013
How to cite
Makhija, I. K., Shreedhara, C. S., & Ram, H. N. A. (2013). Mast cell stabilization potential of Sitopaladi churna: An ayurvedic formulation. Pharmacognosy Research, 5(4), 306–308. https://doi.org/10.4103/0974-8490.118824
Abstract
Background
Sitopaladi churna (SPC) is a popular polyherbal ayurvedic formulation used in the treatment of allergy and respiratory diseases.
Objective
The present study was aimed to justify the classical use of antiallergic claim by performing the mast cell stabilizing activity of extracts of SPC.
Materials and Methods
The protective effect of aqueous extract and methanolic extract - of SPC against compound 48/80-induced mast cell degranulation model was carried out.
Results
Sitopaladi churna aqueous extract (SPCA) at the dose of 300 mg/kg and Sitopaladi churna methanolic extract (SPCM) at the doses of 150 and 300 mg/kg showed better protection of mast cell degranulation (65%-74%) and were comparable to the standard drug ketotifen (79%), when peritoneal mast cells were treated with compound 48/80. The protection against mast cell degranulation was significant (P < 0.0001).
Conclusion
From the above results, it has been justified that SPC can be used to treat allergic disorders.
Keywords
Subject
Article metadata
| Title | Mast cell stabilization potential of Sitopaladi churna: An ayurvedic formulation |
|---|---|
| Authors | Inder K. Makhija; Chandrashekara S. Shreedhara; H. N. Aswatha Ram |
| Affiliations | Department of Pharmacognosy, Manipal College of Pharmaceutical Sciences, Manipal University, Karnataka, India |
| Corresponding author | aswatharam@gmail.com |
| Journal | Pharmacognosy Research |
| Volume / Issue | Vol. 5, Issue 4 (2013) |
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