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ORIGINAL ARTICLEPharmacognosy ResearchVol. 6 | Issue 3 | 2014 | pp. 199–203Open access
Ameliorative effect of Matricaria chamomilla.L on paraquat: Induced oxidative damage in lung rats
- 1*,
- 2,
- 2,
- 3,
- 4,
- 4
- 1 Department of Toxicology and Pharmacology, School of Pharmacy, Hamadan University of Medical Sciences
- 2 Biology, Laboratory of Plant Cell Biology
- 3 Department of Chemistry, Bu-Ali Sina University
- 4 Biochemistry, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
Published in Pharmacognosy Research
Correspondence: Akram Ranjbar
Department of Toxicology and Pharmacology, School of Pharmacy, Hamadan University of Medical Sciences
Email: akranjbar1389@yahoo.com
Copyright: © 2014 Manuscript Technomedia. This is an open access article.
- Published:
- Jan 1, 2014
How to cite
Ranjbar, A., Mohsenzadeh, F., Chehregani, A., Khajavi, F., Zijoud, S. M. H., & Ghasemi, H. (2014). Ameliorative effect of Matricaria chamomilla.L on paraquat: Induced oxidative damage in lung rats. Pharmacognosy Research, 6(3), 199–203. https://doi.org/10.4103/0974-8490.132595
Abstract
Background
Herbal medicines have been long used for antioxidant properties. The purpose of this study was to investigate the effect of hydroalcholic extract Matricaria chamomilla. L (M. chamomilla) against Paraquat (PQ) induced pulmonary injury in association with its antioxidant activity.
Materials and Methods
Effective doses of PQ (5 mg/kg/day) and M. chamomilla (50 mg/kg/day) were administered alone or in combination for 7 days. At the end of the experiment, lung tissue of the animals was separated. The activity of enzymatic scavengers such as glutathione peroxidase (GPx) and superoxide dismutase (SOD), lipid peroxidation (LPO) and total antioxidant power (TAP) were measured.
Results
In these samples, the LPO, SOD, and GPx were higher in the PQ group as compared with controls. M. chamomilla extract ameliorated LPO, SOD, GPx and increased TAP in plasma and lung tissue of PQ induced changes. Co administration of PQ with M. chamomilla improved LPO and SOD, and GPx.
Conclusion
M. chamomilla as natural antioxidant may be considered beneficial for the protection oxidative lung injury in PQ poisoning.
Keywords
Subject
Article metadata
| Title | Ameliorative effect of Matricaria chamomilla.L on paraquat: Induced oxidative damage in lung rats |
|---|---|
| Authors | Akram Ranjbar; Fariba Mohsenzadeh; Abdolkarim Chehregani; Farzad Khajavi; Seyed-Mostafa Hossini Zijoud; Hassan Ghasemi |
| Affiliations | Department of Toxicology and Pharmacology, School of Pharmacy, Hamadan University of Medical Sciences; Biology, Laboratory of Plant Cell Biology; Department of Chemistry, Bu-Ali Sina University; Biochemistry, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran |
| Corresponding author | akranjbar1389@yahoo.com |
| Journal | Pharmacognosy Research |
| Volume / Issue | Vol. 6, Issue 3 (2014) |
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