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ORIGINAL ARTICLEPharmacognosy ResearchVol. 7 | Issue 1 | 2015 | pp. 105–109Open access
Anti-quorum sensing potential of Adenanthera pavonina
- 1,
- 1,
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- 1 Yenepoya Research Center, Yenepoya University, University Road, Deralakatte, Mangalore, Karnataka, India
Published in Pharmacognosy Research
Correspondence: Punchappady-Devasya Rekha
Yenepoya Research Center, Yenepoya University, University Road, Deralakatte, Mangalore, Karnataka, India
Email: dydirectoryrc@yenepoya.edu.in
Copyright: © 2015 Manuscript Technomedia. This is an open access article.
- Published:
- Jan 1, 2015
How to cite
Vasavi, H. S., Arun, A. B., & Rekha, P. D. (2015). Anti-quorum sensing potential of Adenanthera pavonina. Pharmacognosy Research, 7(1), 105–109. https://doi.org/10.4103/0974-8490.147220
Abstract
Background
Quorum sensing (QS) in Pseudomonas aeruginosa plays a key role in virulence factor production, biofilm formation and antimicrobial resistance. Because of emerging antimicrobial resistance in P. aeruginosa, there is a need to find an alternate nonantibiotic agent for the control of infections caused by this organism. Objective: To evaluate anti-QS activity of Adenanthera pavonina L., a medicinal plant used in traditional medicine.
Materials and Methods
Preliminary screening for anti-QS activity of ethanol extract of A. pavonina was carried out using Chromobacterium violaceum CV026 biosensor strain and inhibition of QS-regulated violacein production was quantified using C. violaceum ATCC12472. Bioassay guided fractionation of ethanol extract resulted in ethyl acetate fraction (AEF) with strong anti-QS activity and AEF was evaluated for inhibition of QS-regulated pyocyanin production, proteolytic, elastolytic activity, swarming motility and biofilm formation in P. aeruginosaPAO1.
Results
AEF, at 0.5 mg/ml, inhibited pyocyanin production completely and at 1 mg/ml of AEF, complete inhibition of proteolytic and elastolytic activities were observed. However, viability of P. aeruginosa PAO1 was not affected at the tested concentrations of AEF as observed by cell count. Swarming motility was inhibited at the concentration of 0.1 mg/ml of AEF. Thin layer chromatography and biosensor overlay of AEF showed violacein inhibition zone at Rf value 0.63.
Conclusion
From the results of this study, it can be concluded that A. pavonina extracts can be used as effective anti-QS agents.
Keywords
Subject
Article metadata
| Title | Anti-quorum sensing potential of Adenanthera pavonina |
|---|---|
| Authors | Halkare Suryanarayana Vasavi; Ananthapadmanabha Bhagwath Arun; Punchappady-Devasya Rekha |
| Affiliations | Yenepoya Research Center, Yenepoya University, University Road, Deralakatte, Mangalore, Karnataka, India |
| Corresponding author | dydirectoryrc@yenepoya.edu.in |
| Journal | Pharmacognosy Research |
| Volume / Issue | Vol. 7, Issue 1 (2015) |
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