Open access · Peer reviewed · No APCs
ORIGINAL ARTICLEPharmacognosy ResearchVol. 7 | Issue 2 | 2015 | pp. 193–197Open access
A study of Nigella sativa induced growth inhibition of MCF and HepG2 cell lines: An anti-neoplastic study along with its mechanism of action
- 1,
- 3,
- 2*
- 1 Departments of Pharmaceutcal Analysis
- 2 Pharmacology, Raghavendra Institute of Pharmaceutical Education and Research
- 3 Department of Chemistry, JNTUA, Ananthapuramu, Andhra Pradesh, India
Published in Pharmacognosy Research
Correspondence: Mohammed Jaffar Sadiq
Pharmacology, Raghavendra Institute of Pharmaceutical Education and Research
Email: jaffar909@yahoo.com
Copyright: © 2015 Manuscript Technomedia. This is an open access article.
- Published:
- Jan 1, 2015
How to cite
Reddy, Y. P., Chandrasekhar, K. B., & Sadiq, M. J. (2015). A study of Nigella sativa induced growth inhibition of MCF and HepG2 cell lines: An anti-neoplastic study along with its mechanism of action. Pharmacognosy Research, 7(2), 193–197. https://doi.org/10.4103/0974-8490.150541
Abstract
Objective
To evaluate the anticancer potential of seeds of Nigella sativa using MCF and HepG2 cell lines along with its mechanism of action.
Materials and Methods
(3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay and acridine orange/ethidium bromide nuclear staining technique were selected to evaluate anticancer potential and mechanism of action of test extract.
Results
Aqueous extract of N.sativa at a test dose of 180 mg and 300 mg was identified to be the best as anticancer agent against MCF and HepG2 cell lines among different solvent test extract where doxorubicin and cisplatin were employed as standard references.
Discussion
Further study including separation and characterization of active principles in the aqueous extract shall prove beneficial.
Keywords
Subject
Article metadata
| Title | A study of Nigella sativa induced growth inhibition of MCF and HepG2 cell lines: An anti-neoplastic study along with its mechanism of action |
|---|---|
| Authors | Y. Padmanabha Reddy; K. B. Chandrasekhar; Mohammed Jaffar Sadiq |
| Affiliations | Departments of Pharmaceutcal Analysis; Pharmacology, Raghavendra Institute of Pharmaceutical Education and Research; Department of Chemistry, JNTUA, Ananthapuramu, Andhra Pradesh, India |
| Corresponding author | jaffar909@yahoo.com |
| Journal | Pharmacognosy Research |
| Volume / Issue | Vol. 7, Issue 2 (2015) |
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