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SHORT COMMUNICATIONPharmacognosy ResearchVol. 7 | Issue 2 | 2015 | pp. 213–216Open access
In vivo anti-inflammatory and antiarthritic activities of aqueous extracts from Thymelaea hirsuta
- 1,
- 1*
- 1 Department of Biology, Faculty of Sciences Ain Chock, Laboratory of Physiology and Molecular Genetics, Immunology Unit, University Hassan II, B.P. 5366, Mâarif, Casablanca, Morocco
Published in Pharmacognosy Research
Correspondence: Mounia Oudghiri
Department of Biology, Faculty of Sciences Ain Chock, Laboratory of Physiology and Molecular Genetics, Immunology Unit, University Hassan II, B.P. 5366, Mâarif, Casablanca, Morocco
Email: mouniaoudghiri@gmail.com
Copyright: © 2015 Manuscript Technomedia. This is an open access article.
- Published:
- Jan 1, 2015
How to cite
Azza, Z., & Oudghiri, M. (2015). In vivo anti-inflammatory and antiarthritic activities of aqueous extracts from Thymelaea hirsuta. Pharmacognosy Research, 7(2), 213–216. https://doi.org/10.4103/0974-8490.150510
Abstract
Background
The aerial parts of Thymelaea hirsuta (TH) are used as a decoction in the treatment of different pathologies in folk medicine in Morocco.
Objective
The aqueous extracts were evaluated for its anti-inflammatory activity and in inhibition of adjuvant induction arthritis in male Wistar rats.
Materials and Methods
The anti-inflammatory activity was carried out using carrageenan-induced rat paw edema model, and the antiarthritic activity was carried out using complete Freund’s adjuvant-induced arthritis model.
Results
The plant extract (500 mg/kg body weight) exhibited significant activity in acute inflammation produced 60% of inhibition after 4 h as compared with that of the standard anti-inflammatory drug, the diclofenac (100 mg/kg) which showed 40% of inhibition. In arthritis model, the extract produced 85% inhibition after 18 days when compared with the diclofenac (10 mg/kg; 72%).
Conclusion
These results indicate that the aqueous extract of TH had an anti-inflammatory activity and inhibited the induction of adjuvant arthritis in male Wistar rats.
Keywords
Subject
Article metadata
| Title | In vivo anti-inflammatory and antiarthritic activities of aqueous extracts from Thymelaea hirsuta |
|---|---|
| Authors | Zora Azza; Mounia Oudghiri |
| Affiliations | Department of Biology, Faculty of Sciences Ain Chock, Laboratory of Physiology and Molecular Genetics, Immunology Unit, University Hassan II, B.P. 5366, Mâarif, Casablanca, Morocco |
| Corresponding author | mouniaoudghiri@gmail.com |
| Journal | Pharmacognosy Research |
| Volume / Issue | Vol. 7, Issue 2 (2015) |
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