Open access · Peer reviewed · No APCs
ORIGINAL ARTICLEPharmacognosy ResearchVol. 7 | Issue 4 | 2015 | pp. 367–377Open access
Anti-inflammatory and anti-arthritic activity of a methanol extract from Vitellaria paradoxa stem bark
- 1*,
- 1,
- 2,
- 2,
- 2,
- 3
- 1 Department of Biological Sciences, Faculty of Sciences, University of Maroua, P.O Box 814
- 2 Department of Earth and Life Sciences, Higher Teachers’ Training College, University of Maroua, P.O Box 55, Maroua
- 3 Department of Organic Chemistry, University of Yaounde I, P.O. Box 812, Yaounde, Cameroon
Published in Pharmacognosy Research
Correspondence: Harquin Simplice Foyet
Department of Biological Sciences, Faculty of Sciences, University of Maroua, P.O Box 814
Email: fharquins@gmail.com
Copyright: © 2015 Manuscript Technomedia. This is an open access article.
- Published:
- Jan 1, 2015
How to cite
Foyet, H. S., Tsala, D. E., J.C, Z. E. B., Carine, A. N., Heroyne, L. T., & Oben, E. K. (2015). Anti-inflammatory and anti-arthritic activity of a methanol extract from Vitellaria paradoxa stem bark. Pharmacognosy Research, 7(4), 367–377. https://doi.org/10.4103/0974-8490.159569
Abstract
Background
Vitellaria paradoxa is a traditional medicinal plant of Cameroon. Several studies on this plant have focused on the cosmetic profile of its fruits. The present study focuses on the anti-inflammatory potency of stem barks extract of this plant.
Objective
The objective was to evaluate the effect of methanolic extract of V. paradoxa (VPME) stem barks on inflammatory response in rats.
Materials and Methods
Anti-inflammatory effects of VPME were evaluated in acute and chronic (28 days) inflammation induced in Wistar albino rats. The effects on hyperalgesia and locomotors activity were also quantified. The relative weight of lymphoid organs was obtained as well as some hematological parameters.
Results
In the carrageenan-induced inflammation, VPME (75 mg/kg) exhibited a significant (66.67%) inhibition after 1 h. On the complete Freund’s adjuvant-induced rheumatoid arthritis, VPME showed a significant protective effect with 8.12% inflammation against 25.00% for the control group after 2 days of the treatment. The extract (75 and 150 mg/kg) significantly reduced the score of arthritis with a maximum obtained on day 19th of the experimentation. There was a significant increase in the reaction time of rats on the hot plate as well as the exploratory activities of the animals in the open field. This extract significantly prevented weight, hemoglobin and red blood cells losses, and spleen hypertrophy. A protective action against skin destruction and cartilage erosion was evident. Liquid chromatography-mass spectrometry analysis of the extract revealed the presence of catechins.
Conclusions
These findings suggested that V. paradoxa may contribute to the reduction of the inflammatory response.
Keywords
Subject
Article metadata
| Title | Anti-inflammatory and anti-arthritic activity of a methanol extract from Vitellaria paradoxa stem bark |
|---|---|
| Authors | Harquin Simplice Foyet; David Emery Tsala; Zogo Essono Bodo J.C; Azanfack Name Carine; Lissia Toussoumna Heroyne; Eyong Kenneth Oben |
| Affiliations | Department of Biological Sciences, Faculty of Sciences, University of Maroua, P.O Box 814; Department of Earth and Life Sciences, Higher Teachers’ Training College, University of Maroua, P.O Box 55, Maroua; Department of Organic Chemistry, University of Yaounde I, P.O. Box 812, Yaounde, Cameroon |
| Corresponding author | fharquins@gmail.com |
| Journal | Pharmacognosy Research |
| Volume / Issue | Vol. 7, Issue 4 (2015) |
Also in this issue
- Bioactive compounds from Carissa opaca roots and xanthine oxidase and alpha-amylase inhibitory activities of their methanolic extract and its fractions in different solventspp. 295–301
- Beliefs, attitudes and self-use of Ayurveda, Yoga and Naturopathy, Unani, Siddha, and Homeopathy medicines among senior pharmacy students: An exploratory insight from Andhra Pradesh, Indiapp. 302–308
- Alpha-amylase inhibitory activity and phytochemical study of Zhumeria majdae Rech. f. and Wendelbopp. 309–313
- Alpha-amylase inhibitory activity and sterol composition of the marine algae, Sargassum glaucescenspp. 314–321
- Antiproliferative evaluation of terpenoids and terpenoid coumarins from Ferulago macrocarpa (Fenzl) Boiss. fruitspp. 322–328
Readers Also Viewed
Development and Validation of UV/visible Spectrophotometric Method for Estimation of Piroxicam from Bulk and Formulation
Sandip Mohan Honmane, Kunal Rajaram Yadav, Yuvraj Dilip Dange
Apr 23, 2025
Effects of Artificial Intelligence on Academic Performance of Library and Information Science University Students: A Meta-Analysis (2023-2025)
Kayode Sunday John Dada
Aug 6, 2026
Bridging Innovation and Impact: A Multidisciplinary Approach to Contemporary Research Challenges
Mueen Ahmed KK
Aug 11, 2026