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Short CommunicationPharmacognosy ResearchVol. 8 | Issue 3 | 2016 | pp. 206–208Open access
Hepatoprotective and Cytotoxic Activities of Abietic Acid from Isodon wightii (Bentham) H. Hara
- 1,
- 1*,
- 2,
- 2
- 1 Department of Biotechnology, Kongunadu Arts and Science College
- 2 Department of Chemistry, Bharathiar University, Coimbatore, Tamil Nadu, India
Published in Pharmacognosy Research
Correspondence: Ramaraj Thirugnanasampandan
Department of Biotechnology, Kongunadu Arts and Science College
Email: rtsampandan@yahoo.com
Copyright: © 2016 Manuscript Technomedia. This is an open access article.
- Published:
- Jan 1, 2016
How to cite
Ramnath, M. G., Thirugnanasampandan, R., Mathusalini, S., & Mohan, P. S. (2016). Hepatoprotective and Cytotoxic Activities of Abietic Acid from Isodon wightii (Bentham) H. Hara. Pharmacognosy Research, 8(3), 206–208. https://doi.org/10.4103/0974-8490.182920
Abstract
Isodon (Lamiaceae) is a known source of bioactive terpenoids. Diterpenoids isolated from Isodon wightii (Bentham) H. Hara showed antibacterial, antiacetylcholinesterase, antioxidant, anticancer, and anticarcinogenic activities, etc., Hepatoprotective activity of ABA against lipopolysaccharide (LPS) induced liver injury in BALB/c mice was studied. Cytotoxic activity of ABA was tested against cervical cancer cells (HeLa) using MTT assay followed by propidium iodide (PI) staining to identify apoptosis. Histopathological analysis revealed that 1.5 mg/mL LPS induced liver damage was attenuated by ABA in a dose dependent manner. ABA showed cytotoxicity with IC50 value of 176.28 ± 0.02 mg/mL and PI staining of treated cells showed apoptosis. This study proves that ABA would be a promising natural compound for herbal drug preparation.
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Article metadata
| Title | Hepatoprotective and Cytotoxic Activities of Abietic Acid from Isodon wightii (Bentham) H. Hara |
|---|---|
| Authors | Madhusudhanan Gogul Ramnath; Ramaraj Thirugnanasampandan; Sadasivam Mathusalini; Palathurai Subramanium Mohan |
| Affiliations | Department of Biotechnology, Kongunadu Arts and Science College; Department of Chemistry, Bharathiar University, Coimbatore, Tamil Nadu, India |
| Corresponding author | rtsampandan@yahoo.com |
| Journal | Pharmacognosy Research |
| Volume / Issue | Vol. 8, Issue 3 (2016) |
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