Open access · Peer reviewed · No APCs
Short CommunicationPharmacognosy ResearchVol. 8 | Issue 3 | 2016 | pp. 206–208Open access
Hepatoprotective and Cytotoxic Activities of Abietic Acid from Isodon wightii (Bentham) H. Hara
- 1,
- 1*,
- 2,
- 2
- 1 Department of Biotechnology, Kongunadu Arts and Science College
- 2 Department of Chemistry, Bharathiar University, Coimbatore, Tamil Nadu, India
Published in Pharmacognosy Research
Correspondence: Ramaraj Thirugnanasampandan
Department of Biotechnology, Kongunadu Arts and Science College
Email: rtsampandan@yahoo.com
Copyright: © 2016 Manuscript Technomedia. This is an open access article.
- Published:
- Jan 1, 2016
How to cite
Ramnath, M. G., Thirugnanasampandan, R., Mathusalini, S., & Mohan, P. S. (2016). Hepatoprotective and Cytotoxic Activities of Abietic Acid from Isodon wightii (Bentham) H. Hara. Pharmacognosy Research, 8(3), 206–208. https://doi.org/10.4103/0974-8490.182920
Abstract
Isodon (Lamiaceae) is a known source of bioactive terpenoids. Diterpenoids isolated from Isodon wightii (Bentham) H. Hara showed antibacterial, antiacetylcholinesterase, antioxidant, anticancer, and anticarcinogenic activities, etc., Hepatoprotective activity of ABA against lipopolysaccharide (LPS) induced liver injury in BALB/c mice was studied. Cytotoxic activity of ABA was tested against cervical cancer cells (HeLa) using MTT assay followed by propidium iodide (PI) staining to identify apoptosis. Histopathological analysis revealed that 1.5 mg/mL LPS induced liver damage was attenuated by ABA in a dose dependent manner. ABA showed cytotoxicity with IC50 value of 176.28 ± 0.02 mg/mL and PI staining of treated cells showed apoptosis. This study proves that ABA would be a promising natural compound for herbal drug preparation.
Keywords
Subject
Article metadata
| Title | Hepatoprotective and Cytotoxic Activities of Abietic Acid from Isodon wightii (Bentham) H. Hara |
|---|---|
| Authors | Madhusudhanan Gogul Ramnath; Ramaraj Thirugnanasampandan; Sadasivam Mathusalini; Palathurai Subramanium Mohan |
| Affiliations | Department of Biotechnology, Kongunadu Arts and Science College; Department of Chemistry, Bharathiar University, Coimbatore, Tamil Nadu, India |
| Corresponding author | rtsampandan@yahoo.com |
| Journal | Pharmacognosy Research |
| Volume / Issue | Vol. 8, Issue 3 (2016) |
Also in this issue
- Efficacy of Oral Curcuminoid Fraction from Curcuma xanthorrhiza and Curcuminoid Cider in High-cholesterol Fed Ratspp. 153–159
- Evaluation of Skin Anti-aging Potential of Citrus reticulata Blanco Peelpp. 160–168
- Assessment of Effectiveness of Barleria prionitis on Oral Healthpp. 169–172
- Evaluation of Efficacy of Herbal Intrauterine Infusion Uterofix Liquid in Treatment of Various Reproductive Disorders in Cows: A Field Studypp. 173–175
- Effects of Five Bangladeshi Plant Extracts on In vitro Thrombolysis and Cytotoxicitypp. 176–180
Readers Also Viewed
Development and Validation of UV/visible Spectrophotometric Method for Estimation of Piroxicam from Bulk and Formulation
Sandip Mohan Honmane, Kunal Rajaram Yadav, Yuvraj Dilip Dange
Apr 23, 2025
Effects of Artificial Intelligence on Academic Performance of Library and Information Science University Students: A Meta-Analysis (2023-2025)
Kayode Sunday John Dada
Aug 6, 2026
Bridging Innovation and Impact: A Multidisciplinary Approach to Contemporary Research Challenges
Mueen Ahmed KK
Aug 11, 2026