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Original ArticlePharmacognosy ResearchVol. 8 | Issue 5s | 2016 | pp. S1–S4Open access
Anti-Leishmania Activity of Osthole
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- 1 Department of Pharmacognosy, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan
- 2 Department of Medical Parasitology and Mycology, School of Medicine, Isfahan University of Medical Sciences, Isfahan
- 3 Department of Medical Parasitology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
Published in Pharmacognosy Research
Correspondence: Elaheh Kordzadeh Kermani
Department of Pharmacognosy, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan
Email: kordzadeh.elahe@gmail.com
Copyright: © 2016 Manuscript Technomedia. This is an open access article.
- Published:
- Jan 1, 2016
How to cite
Kermani, E. K., Sajjadi, S. E., Hejazi, S. H., Arjmand, R., Saberi, S., & Eskandarian, A. A. (2016). Anti-Leishmania Activity of Osthole. Pharmacognosy Research, 8(5s), S1–S4. https://doi.org/10.4103/0974-8490.178650
Abstract
Background
Treatment of cutaneous leishmaniasis (CL) is occasionally highly resistant to pentavalent antimonials, the gold standard in pharmacotherapy of CL. Since there is no effective vaccine, the discovery of natural antileishmanial products as complementary therapeutic agents could be used to improve the current regimens.
Objective
In this study in~vitro and in~vivo antileishmanial activities of osthole, a natural coumarin known to possess antibacterial and parasiticidal activities are evaluated.
Materials and Methods
Leishmania major infected J774.A1 macrophages were treated with increasing concentrations of osthole. CL lesions of BALB/c mice were treated topically with 0.2% osthole.
Results
Osthole exhibited dose-dependent leishmanicidal activity against intracellular amastigotes with IC50 value of 14.95 mg/ml. Treatment of CL lesions in BALB/c mice with osthole significantly declined lesion progression compared to untreated mice (P < 0.05), however did not result in recovery.
Conclusion
Osthole demonstrated remarkable leishmanicidal activity in~ vitro. Higher concentrations of osthole may demonstrate the therapeutic property in~vivo.
Keywords
Subject
Article metadata
| Title | Anti-Leishmania Activity of Osthole |
|---|---|
| Authors | Elaheh Kordzadeh Kermani; Seyed Ebrahim Sajjadi; Seyed Hossein Hejazi; Reza Arjmand; Sedigheh Saberi; Abbas Ali Eskandarian |
| Affiliations | Department of Pharmacognosy, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan; Department of Medical Parasitology and Mycology, School of Medicine, Isfahan University of Medical Sciences, Isfahan; Department of Medical Parasitology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran |
| Corresponding author | kordzadeh.elahe@gmail.com |
| Journal | Pharmacognosy Research |
| Volume / Issue | Vol. 8, Issue 5s (2016) |
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