Open access · Peer reviewed · No APCs
Original ArticlePharmacognosy ResearchVol. 9 | Issue 1 | 2026 | pp. 80–86Open access
Antidiabetic Effects of Aqueous and Dichloromethane/Methanol Stem Bark Extracts of Pterocarpus soyauxii Taub (Papilionaceae) on Streptozotocin‑induced Diabetic Rats
- 1*,
- 2,
- 3,
- 3,
- 2,
- 2
- 1 Department of Animal Biology Organisms, Faculty of Science, University of Douala, 24157, Douala; Department of Animal Biology and Physiology, Faculty of Science, University of Yaounde 1, 812, Yaounde, Cameroon; INSERM, U1048, I2MC Institute of Metabolic and Cardiovascular diseases, University of Toulouse III, F31432, Toulouse, FRANCE.
- 2 Department of Animal Biology and Physiology, Faculty of Science, University of Yaounde 1, 812, Yaounde, CAMEROON.
- 3 INSERM, U1048, I2MC Institute of Metabolic and Cardiovascular diseases, University of Toulouse III, F31432, Toulouse, FRANCE.
Published in Pharmacognosy Research
Correspondence: Marie Claire Tchamadeu
Department of Animal Biology Organisms, Faculty of Science, University of Douala, 24157, Douala; Department of Animal Biology and Physiology, Faculty of Science, University of Yaounde 1, 812, Yaounde, Cameroon; INSERM, U1048, I2MC Institute of Metabolic and Cardiovascular diseases, University of Toulouse III, F31432, Toulouse, FRANCE.
Email: marieclaire_tchamadeu@yahoo.fr
Copyright: © 2026 Manuscript Technomedia. This is an open access article.
- Published:
- Aug 14, 2026
How to cite
Tchamadeu, M. C., Dzeufiet, P. D. D., Blaes, N., Girolami, J. P., Kamtchouing, P., & Dimo, T. (2026). Antidiabetic Effects of Aqueous and Dichloromethane/Methanol Stem Bark Extracts of Pterocarpus soyauxii Taub (Papilionaceae) on Streptozotocin‑induced Diabetic Rats. Pharmacognosy Research, 9(1), 80–86. https://doi.org/10.4103/0974-8490.199767
Abstract
Aim of the Study: The aim is to evaluate the hypoglycemic and antidiabetic effects of aqueous and CH2Cl2/CH3OH stem bark extracts of Pterocarpus soyauxii Taub in normal and diabetic rats. Materials and Methods: Streptozotocin (STZ)‑induced diabetic and normal adult Wistar rats were orally administered with aqueous and CH2Cl2/CH3OH plant extracts of P. soyauxii at various doses (38–300 mg/kg) in a single administration. In addition, STZ‑induced diabetic rats received prolonged daily administration for 14 days. Glibenclamide (GB) (10 mg/kg) was used as reference treatment. In acute test, fasting blood glucose was followed for 5 h. In subacute test, body weight, food and water intakes, and blood glucose were followed weekly and serum biochemical parameters evaluated after 14 days treatment. Results: Acute administration of aqueous and CH2Cl2/ CH3OH stem bark extracts moderately decreased fasting blood glucose compared to GB, significantly in normal rats (P < 0.05 to P < 0.01) but, as GB, not significantly in diabetic rats. Prolonged treatments in diabetic rats with aqueous and CH2Cl2/CH3OH extracts reduced blood glucose to an extent, respectively, superior or similar to GB. Moreover, P. soyauxii also significantly (P < 0.01) reduced weight loss, and diabetes increased serum triglycerides, total cholesterol, and transaminases (alanine aminotransferase/ aspartate aminotransferase) elevations. Conclusion: P. soyauxii Taub stem bark extracts have possible value for antidiabetic oral medication.
Keywords
Subject
Article metadata
| Title | Antidiabetic Effects of Aqueous and Dichloromethane/Methanol Stem Bark Extracts of Pterocarpus soyauxii Taub (Papilionaceae) on Streptozotocin‑induced Diabetic Rats |
|---|---|
| Authors | Marie Claire Tchamadeu; Paul Désiré Djomeni Dzeufiet; Nelly Blaes; Jean-Pierre Girolami; Pierre Kamtchouing; Théophile Dimo |
| Affiliations | Department of Animal Biology Organisms, Faculty of Science, University of Douala, 24157, Douala; Department of Animal Biology and Physiology, Faculty of Science, University of Yaounde 1, 812, Yaounde, Cameroon; INSERM, U1048, I2MC Institute of Metabolic and Cardiovascular diseases, University of Toulouse III, F31432, Toulouse, FRANCE.; Department of Animal Biology and Physiology, Faculty of Science, University of Yaounde 1, 812, Yaounde, CAMEROON.; INSERM, U1048, I2MC Institute of Metabolic and Cardiovascular diseases, University of Toulouse III, F31432, Toulouse, FRANCE. |
| Corresponding author | marieclaire_tchamadeu@yahoo.fr |
| Journal | Pharmacognosy Research |
| Volume / Issue | Vol. 9, Issue 1 (2026) |
Also in this issue
- Antihyperglycemic Activity of the Leaves from Annona cherimola Miller and Rutin on Alloxan-induced Diabetic Ratspp. 1–6
- Methanol Extract of Adansonia digitata Leaf Protects Against Sodium Arsenite‑induced Toxicities in Male Wistar Ratspp. 7–11
- The Influence of Pluronic F68 and F127 Nanocarrier on Physicochemical Properties, In vitro Release, and Antiproliferative Activity of Thymoquinone Drugpp. 12–20
- Evaluation of Cholesterol‑lowering Activity of Standardized Extract of Mangifera indica in Albino Wistar Ratspp. 21–26
- Chronic Intake of Green Propolis Negatively Affecting the Rat Testispp. 27–33
Readers Also Viewed
Development and Validation of UV/visible Spectrophotometric Method for Estimation of Piroxicam from Bulk and Formulation
Sandip Mohan Honmane, Kunal Rajaram Yadav, Yuvraj Dilip Dange
Apr 23, 2025
Effects of Artificial Intelligence on Academic Performance of Library and Information Science University Students: A Meta-Analysis (2023-2025)
Kayode Sunday John Dada
Aug 6, 2026
Bridging Innovation and Impact: A Multidisciplinary Approach to Contemporary Research Challenges
Mueen Ahmed KK
Aug 11, 2026