Open access · Peer reviewed · No APCs
Original ArticlePharmacognosy ResearchVol. 9 | Issue 5s | 2026 | pp. s23–s26Open access
Antihyperglycemic Potential of Saponin-enriched Fraction from Pithecellobium dulce Benth. Seed Extract
- 1,2*,
- 1,2,
- 2
- 1 Faculty of Pharmacy, Rajasthan University of Health Sciences, Jaipur.
- 2 Department of Pharmacognosy, Alwar College of Pharmacy, Alwar, Rajasthan, India.
Published in Pharmacognosy Research
Correspondence: Mahesh Kumar
Faculty of Pharmacy, Rajasthan University of Health Sciences, Jaipur.; Department of Pharmacognosy, Alwar College of Pharmacy, Alwar, Rajasthan, India.
Email: mkmmchem@gmail.com
Copyright: © 2026 Manuscript Technomedia. This is an open access article.
- Published:
- Aug 14, 2026
- DOI:
- 10.4103/pr.pr_18_17
How to cite
Kumar, M., Govindrajan, J., & Nyola, N. K. (2026). Antihyperglycemic Potential of Saponin-enriched Fraction from Pithecellobium dulce Benth. Seed Extract. Pharmacognosy Research, 9(5s), s23–s26. https://doi.org/10.4103/pr.pr_18_17
Abstract
Background: Indian traditional system of medicine uses Pithecellobium dulce for the treatment of diabetes mellitus. Objectives: This study aims to develop an extract rich in saponins derived from seeds of the plant and to evaluate its antihyperglycemic potential in vitro and in vivo. Materials and Methods: Defatted seeds were extracted with methanol and processed to afford saponin-enriched fraction (PDSEF). The fraction was evaluated for α-glucosidase and α-amylase inhibition. Results: PDSEF showed superior enzyme inhibition compared to acarbose and was safe up to 2000 mg/kg. Conclusion: PDSEF displayed excellent antihyperglycemic activity in vitro and in vivo.
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Article metadata
| Title | Antihyperglycemic Potential of Saponin-enriched Fraction from Pithecellobium dulce Benth. Seed Extract |
|---|---|
| Authors | Mahesh Kumar; Jeyabalan Govindrajan; Narendra Kumar Nyola |
| Affiliations | Faculty of Pharmacy, Rajasthan University of Health Sciences, Jaipur.; Department of Pharmacognosy, Alwar College of Pharmacy, Alwar, Rajasthan, India. |
| Corresponding author | mkmmchem@gmail.com |
| Journal | Pharmacognosy Research |
| Volume / Issue | Vol. 9, Issue 5s (2026) |
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