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Original ArticleFree Radicals and AntioxidantsVol. 3 | Issue 2 | 2013 | pp. 93–99Open access
Modulation of redox homeostasis by Lamiaceae herbs in seminal vesicles of Lumbricus terrestris
- 1*,
- 1
- 1 Nutrition Biomedicine and Biotechnology Laboratory, School of Family and Consumer Sciences, Texas State University, San Marcos, TX 78666, USA.
Published in Free Radicals and Antioxidants
Correspondence: Dhiraj Anil Vattem
Nutrition Biomedicine and Biotechnology Laboratory, School of Family and Consumer Sciences, Texas State University, San Marcos, TX 78666, USA.
Email: dv11@txstate.edu
Copyright: © 2013 Manuscript Technomedia. This is an open access article.
- Published:
- Aug 23, 2013
- Received:
- Mar 27, 2013
- Accepted:
- Aug 20, 2013
How to cite
Vattem, D. A., & DeLeon, R. C. (2013). Modulation of redox homeostasis by Lamiaceae herbs in seminal vesicles of Lumbricus terrestris. Free Radicals and Antioxidants, 3(2), 93–99. https://doi.org/10.1016/j.fra.2013.05.003
Abstract
Background/Aims: Health benefits of Lamiaceae herbs are attributed to the presence of antioxidant phytochemicals. However, mechanism of in vivo functionality is not very well understood. We deter- mined the in vivo effect of dietary Lamiaceae herbs on modulating redox-nitric oxide (NO) homeostasis and sperm quality in oxidation prone environment of seminal vesicles in Lumbricus terrestris. Methods: Animals fed ad libitum on Lumbricus growth medium supplemented with 0% (control), 0.1% or 0.5% (w/v) of different herbs. The seminal vesicles of the animal were dissected out on day 2 and day 6, and gently disrupted. Levels of malondialdehyde (MDA), DNA fragmentation (DNAF), glutathione (GSH), nitrates/nitrites (NOx), superoxide dismutase (SOD), catalase (CAT) were determined using standard assays. Sperm maturity and deformation (DFO) was quantified microscopically. Results: Overall, the herb treatments decreased MDA levels by (60e90%), increased SOD activity (15e50%), and decreased DNAF (6e11%). Treatments with basil and oregano at 0.1% (w/v) were most effective. Conclusion: Our suggests that phytochemicals from Lamiaceae herbs modulate redox stress response, and protect against oxidative stress in seminal vesicles.
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Article metadata
| Title | Modulation of redox homeostasis by Lamiaceae herbs in seminal vesicles of Lumbricus terrestris |
|---|---|
| Authors | Dhiraj Anil Vattem; Robert Corey DeLeon |
| Affiliations | Nutrition Biomedicine and Biotechnology Laboratory, School of Family and Consumer Sciences, Texas State University, San Marcos, TX 78666, USA. |
| Corresponding author | dv11@txstate.edu |
| Journal | Free Radicals and Antioxidants |
| Volume / Issue | Vol. 3, Issue 2 (2013) |
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