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Original ArticleFree Radicals and AntioxidantsVol. 3 | Issue 2 | 2013 | pp. S50–S54Open access
Synthesis of (4-benzoyl-phenoxy)-acetic acid derivatives and their efficacy as antioxidant agents
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- 1 Department of Chemistry, Yuvaraja College, University of Mysore, Mysore 570 005, Karnataka, INDIA.
- 2 Department of Chemistry, D. Banumaih’s P U Science College, Mysore 570 024, Karnataka, INDIA.
Published in Free Radicals and Antioxidants
Correspondence: Shaukath Ara Khanum
Department of Chemistry, Yuvaraja College, University of Mysore, Mysore 570 005, Karnataka, INDIA.
Email: shaukathara@yahoo.co.in
Copyright: © 2013 Manuscript Technomedia. This is an open access article.
- Published:
- Aug 23, 2013
How to cite
Prashanth, T., Ranganatha, V. L., Naveen, P., Gurupadaswamy, H., Begum, A. B., Al-Ghorbani, M., & Khanum, S. A. (2013). Synthesis of (4-benzoyl-phenoxy)-acetic acid derivatives and their efficacy as antioxidant agents. Free Radicals and Antioxidants, 3(2), S50–S54. https://doi.org/10.1016/j.fra.2013.09.002
Abstract
Aim & background: To study the synthesis of a series of (4-benzoyl-phenoxy)-acetic acid derivatives (6aek) and to test their antioxidant activity. Methods: The newly synthesized compounds were characterized by IR, 1 H NMR and LCeMS analyses. All these compounds were screened for their in vitro antioxidant activity by employing 1,1-diphenyl-1- picrylhydrazyl (DPPH), nitric oxide (NO) and hydrogen peroxide (H2O2) radical scavenging assays. Results: Compounds 6h with chloro substituent in benzoyl ring and 6f with no substituent in benzoyl ring showed good radical scavenging activity in all the three methods compared to the standard drug ascorbic acid. Whereas compound 6k with methoxy substituent in benzoyl ring showed good antioxidant activity only in hydrogen peroxide method and remaining compounds showed moderate to mild radical scavenging activity. Conclusion: Compounds 6f, 6h and 6i showed excellent activity, almost equivalent to that of standard and the remaining compounds showed moderate to mild scavenging activity.
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Article metadata
| Title | Synthesis of (4-benzoyl-phenoxy)-acetic acid derivatives and their efficacy as antioxidant agents |
|---|---|
| Authors | T. Prashanth; V. Lakshmi Ranganatha; P. Naveen; H.D. Gurupadaswamy; A. Bushra Begum; Mohammed Al-Ghorbani; Shaukath Ara Khanum |
| Affiliations | Department of Chemistry, Yuvaraja College, University of Mysore, Mysore 570 005, Karnataka, INDIA.; Department of Chemistry, D. Banumaih’s P U Science College, Mysore 570 024, Karnataka, INDIA. |
| Corresponding author | shaukathara@yahoo.co.in |
| Journal | Free Radicals and Antioxidants |
| Volume / Issue | Vol. 3, Issue 2 (2013) |
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