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Pharmaceutical ResearchIndian Journal of Pharmaceutical Education and ResearchVol. 50 | Issue 1 | 2015 | pp. 179–189Open access
Screening of Ethanolic extract of Diospyros malabarica Desr. Bark for Anti-diabetic and Antioxidant Potential
- 1,
- 2*
- 1 Department of Pharmaceutical Biotechnology, K.L.E. University, College of Pharmacy, Nehru nagar, Belagavi-10, Karnataka, India.
- 2 K.L.E.U College of Pharmacy and Dr. Prabhakar Kore Basic Science Research Center [BSRC], KLE University, Nehru nagar, Belagavi-590010, Karnataka, India.
Published in Indian Journal of Pharmaceutical Education and Research
Correspondence: Sunil Satyappa Jalalpure
K.L.E.U College of Pharmacy and Dr. Prabhakar Kore Basic Science Research Center [BSRC], KLE University, Nehru nagar, Belagavi-590010, Karnataka, India.
Email: jalalpuresunil@rediffmail.com
Copyright: © 2015 Manuscript Technomedia. This is an open access article.
- Published:
- Jul 16, 2015
- Received:
- May 15, 2015
- Accepted:
- Jun 26, 2015
How to cite
Kavatagimath, S. A., & Jalalpure, S. S. (2015). Screening of Ethanolic extract of Diospyros malabarica Desr. Bark for Anti-diabetic and Antioxidant Potential. Indian Journal of Pharmaceutical Education and Research, 50(1), 179–189. https://doi.org/10.5530/ijper.50.1.22
Abstract
Objective: Evaluation of ethanolic extract of Diospyrous malabarica Desr. Bark for anti-diabetic and antioxidant potentials. Materials and Methods: Diospyros malabarica Desr. bark ethanol extract was studied for the OGTT study and acute and sub-acute effects on alloxan induced diabetic rats. Blood glucose levels, Serum lipid profiles and histopathological study of pancreas were performed. The Bark extract was also studied for DPPH radical scavenging potential. Results: Ethanolic extract of bark of Diospyros malabarica significantly improved the glucose tolerance test upto 4h., approximately, 17% and 29% reduction in blood glucose level was observed at 2 h and 4 h respectively. Blood glucose lowering potential percentage was 19% at 6 h in acute studyand after 15 days of treatment it was 39% in Sub acute study. The extract also showed better activity in quenching DPPH radical. Conclusion: Ethanolic extract (200 mg /kg) treated diabetic rats showed partial restoration of normal cellular population and size of islet cells.
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Article metadata
| Title | Screening of Ethanolic extract of Diospyros malabarica Desr. Bark for Anti-diabetic and Antioxidant Potential |
|---|---|
| Authors | Satish Annayya Kavatagimath; Sunil Satyappa Jalalpure |
| Affiliations | Department of Pharmaceutical Biotechnology, K.L.E. University, College of Pharmacy, Nehru nagar, Belagavi-10, Karnataka, India.; K.L.E.U College of Pharmacy and Dr. Prabhakar Kore Basic Science Research Center [BSRC], KLE University, Nehru nagar, Belagavi-590010, Karnataka, India. |
| Corresponding author | jalalpuresunil@rediffmail.com |
| Journal | Indian Journal of Pharmaceutical Education and Research |
| Volume / Issue | Vol. 50, Issue 1 (2015) |
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