Open access · Peer reviewed · No APCs
Original ArticleIndian Journal of Pharmaceutical Education and ResearchVol. 51 | Issue 3 | 2017 | pp. 412–417Open access
Effects of Rutin on Testicular Antioxidant Enzymes and Lipid Peroxidation in Rats
- 1*,
- 2,
- 1,
- 1,
- 1,
- 3,
- 1,
- 4,
- 5,
- 6
- 1 Department of Biotechnology, Faculty of Biological Sciences, University of Science and Technology Bannu, Khyber Pakutunkhwa, PAKISTAN.
- 2 Department of Biochemistry, Faculty of Biological Sciences, Quaid-i-Azam University Islamabad, PAKISTAN.
- 3 Department of Pharmacy, University of Malakand, Chakdara Dir, Khyber Pakutunkhwa, PAKISTAN.
- 4 Department of Biochemistery, Abdul Wali Khan University Mardan, 23200, Khyber Pakutunkhwa, PAKISTAN.
- 5 Department of Plant Breeding and Genetics, .
- 6 Department of Physics Government College University Faisalabad, .
Published in Indian Journal of Pharmaceutical Education and Research
Correspondence: Rahmat Ali Khan
Department of Biotechnology, Faculty of Biological Sciences, University of Science and Technology Bannu, Khyber Pakutunkhwa, PAKISTAN.
Email: rahmatgenetics@gmail.com
Copyright: © 2017 Manuscript Technomedia. This is an open access article.
- Published:
- Jan 22, 2017
- Received:
- Dec 13, 2016
- Accepted:
- Feb 15, 2017
How to cite
Khan, R. A., Khan, M. R., Ahmed, M., Shah, M. S., Rehman, S. U., Khan, J., Husain, M., Khan, F. A., Khan, M. M., & Shifa, M. S. (2017). Effects of Rutin on Testicular Antioxidant Enzymes and Lipid Peroxidation in Rats. Indian Journal of Pharmaceutical Education and Research, 51(3), 412–417. https://doi.org/10.5530/ijper.51.3.69
Abstract
Rutin, a polyphenolic flavonoid, possesses antioxidant and hypoglycemic effects. Objective: The present study was conducted to check the effect of rutin on serum reproductive hormonal level and sperm concentration in male rat. Methods: 30 rats were equally divided into 3 groups (10 rats per group). Group I was control (untreated), group II was given rutin 50 mg/kg bw while group III was given 100 mg/ kg bw intragastric twice a week for four weeks respectively. The effect of rutin on antioxidant enzymes (POD, SOD, GSHpx, GST, GSR), glutathione contents and TBARS contents were checked. Results: The results revealed that rutin caused significant gain in body weight, antioxidant enzymes (POD, SOD, GSHpx, GST, GSR), glutathione contents, with significant (P< 0.01) decrease in thiobarbituric acid reactive substance (TBARS) concentrations. Conclusion: It may be concluded that rutin may be promising as a natural therapeutic agent in male reproductive dysfunction.
Keywords
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Article metadata
| Title | Effects of Rutin on Testicular Antioxidant Enzymes and Lipid Peroxidation in Rats |
|---|---|
| Authors | Rahmat Ali Khan; Muhammad Rashid Khan; Mushtaq Ahmed; Mir Sadiq Shah; Shoiab Ur Rehman; Jahangir Khan; Masroor Husain; Farman Ali Khan; Muhammad Mohibullah Khan; Muhammad Shahzad Shifa |
| Affiliations | Department of Biotechnology, Faculty of Biological Sciences, University of Science and Technology Bannu, Khyber Pakutunkhwa, PAKISTAN.; Department of Biochemistry, Faculty of Biological Sciences, Quaid-i-Azam University Islamabad, PAKISTAN.; Department of Pharmacy, University of Malakand, Chakdara Dir, Khyber Pakutunkhwa, PAKISTAN.; Department of Biochemistery, Abdul Wali Khan University Mardan, 23200, Khyber Pakutunkhwa, PAKISTAN.; Department of Plant Breeding and Genetics, .; Department of Physics Government College University Faisalabad, . |
| Corresponding author | rahmatgenetics@gmail.com |
| Journal | Indian Journal of Pharmaceutical Education and Research |
| Volume / Issue | Vol. 51, Issue 3 (2017) |
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