Open access · Peer reviewed · No APCs
Original ArticleIndian Journal of Pharmaceutical Education and ResearchVol. 52 | Issue 1 | 2018 | pp. 94–100Open access
Antioxidant Properties and Protective Effect of Turkish Propolis on t-BHP-Induced Oxidative Stress in Foreskin Fibroblast Cells
- 1,2*,
- 3,
- 4,
- 5,6,
- 2,
- 3
- 1 Department of Biochemistry, Faculty of Pharmacy, Cumhuriyet University, Sivas, TURKIYE.
- 2 Department of Medical Biochemistry, Institute of Health Sciences, Karadeniz Technical University, Trabzon, TURKIYE.
- 3 Department of Medical Biochemistry, Faculty of Medicine, Karadeniz Technical University, Trabzon, TURKIYE.
- 4 Department of Nutrition and Dietetics, Faculty of Health Sciences, Karadeniz Technical University, Trabzon, TURKIYE.
- 5 Department of Genetic and Bioengineering, Faculty of Engineering and Natural Sciences, Gumushane University, Gumushane, TURKIYE.
- 6 Medicinal Plants, Traditional Medicine Practice and Research Center, Gumushane University, Gumushane, TURKIYE.
Published in Indian Journal of Pharmaceutical Education and Research
Correspondence: Sema Misir
Department of Biochemistry, Faculty of Pharmacy, Cumhuriyet University, Sivas, TURKIYE.; Department of Medical Biochemistry, Institute of Health Sciences, Karadeniz Technical University, Trabzon, TURKIYE.
Email: semay-61@hotmail. com
Copyright: © 2018 Manuscript Technomedia. This is an open access article.
- Published:
- Jan 2, 2018
- Received:
- Mar 8, 2017
- Accepted:
- Jul 28, 2017
How to cite
Misir, S., Aliyazicioglu, Y., Demir, S., Turan, I., Yaman, S. O., & Deger, O. (2018). Antioxidant Properties and Protective Effect of Turkish Propolis on t-BHP-Induced Oxidative Stress in Foreskin Fibroblast Cells. Indian Journal of Pharmaceutical Education and Research, 52(1), 94–100. https://doi.org/10.5530/ijper.52.1.11
Abstract
Objective: Propolis is an important bee product, rich in polyphenolic compounds. It has antitumoral, antioxidant, antimutagenic, and other useful activities. Biological activities of propolis are generally attributed to its substance of polyphenolic compounds. The aim of this study was to investigate the in vitro antioxidant properties and reduction amount of intracellular reactive oxygen species (ROS) in human normal foreskin fibroblast cells by Turkish propolis ethanolic extract (EEP). Method: Total phenolic and flavonoid contents, reducing power, radical scavenging capacity, and iron chelating activity of EEP were determined using spectrophotometric methods. Intracellular ROS levels were determined by spectrofluorometric analysis with CM-H2DCFDA. Results: Our results indicated that antioxidant activity was correlated with the higher total phenolic and flavonoid contents of EEP. The generated ROS levels were significantly decreased by EEP compared to only t-BHP group. Conclusion: Ethanolic propolis extract may be evaluated as a potency antioxidant resource and/or a novel natural agent in food and drug industries.
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Article metadata
| Title | Antioxidant Properties and Protective Effect of Turkish Propolis on t-BHP-Induced Oxidative Stress in Foreskin Fibroblast Cells |
|---|---|
| Authors | Sema Misir; Yuksel Aliyazicioglu; Selim Demir; Ibrahim Turan; Serap Ozer Yaman; Orhan Deger |
| Affiliations | Department of Biochemistry, Faculty of Pharmacy, Cumhuriyet University, Sivas, TURKIYE.; Department of Medical Biochemistry, Institute of Health Sciences, Karadeniz Technical University, Trabzon, TURKIYE.; Department of Medical Biochemistry, Faculty of Medicine, Karadeniz Technical University, Trabzon, TURKIYE.; Department of Nutrition and Dietetics, Faculty of Health Sciences, Karadeniz Technical University, Trabzon, TURKIYE.; Department of Genetic and Bioengineering, Faculty of Engineering and Natural Sciences, Gumushane University, Gumushane, TURKIYE.; Medicinal Plants, Traditional Medicine Practice and Research Center, Gumushane University, Gumushane, TURKIYE. |
| Corresponding author | semay-61@hotmail. com |
| Journal | Indian Journal of Pharmaceutical Education and Research |
| Volume / Issue | Vol. 52, Issue 1 (2018) |
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