Open access · Peer reviewed · No APCs
Original ArticleIndian Journal of Pharmaceutical Education and ResearchVol. 53 | Issue 3 | 2019 | pp. 457–467Open access
Liquisolid Compact Tablet of Candesartan Cilexetil with Enhanced Solubility using Neusilin US2, Aerosil 200 and Transcutol HP
- 1,
- 1,
- 1*
- 1 Department of Pharmaceutics, JSPM Rajarshi Shahu College of Pharmacy and Research, Tathawade, Pune, Maharashtra, INDIA.
Published in Indian Journal of Pharmaceutical Education and Research
Correspondence: Ashlesha Pravin Pandit
Department of Pharmaceutics, JSPM Rajarshi Shahu College of Pharmacy and Research, Tathawade, Pune, Maharashtra, INDIA.
Email: panditashleshap@rediffmail.com
Copyright: © 2019 Manuscript Technomedia. This is an open access article.
- Published:
- Jul 21, 2019
- Received:
- Dec 4, 2018
- Accepted:
- Apr 22, 2019
How to cite
Argade, P., Patole, V. C., & Pandit, A. P. (2019). Liquisolid Compact Tablet of Candesartan Cilexetil with Enhanced Solubility using Neusilin US2, Aerosil 200 and Transcutol HP. Indian Journal of Pharmaceutical Education and Research, 53(3), 457–467. https://doi.org/10.5530/ijper.53.3.78
Abstract
Objective: An attempt was made to enhance solubility, dissolution and intestinal permeability of drug candesartan cilexetil by liquisolid technology. Methods: Liquisolid tablet was formulated using non-volatile solvent Transcutol HP, carrier material Neusilin US2 and coating material Aerosil 200. Appropriate quantities of excipients were calculated with the help of mathematical model to get liquisolid powder. A 32 full-factorial design was used further to optimize liquisolid powder. Results: DSC, XRD and SEM studies revealed absence of crystalline nature of drug in liquisolid powder. Liquisolid powder was further compressed into tablet and subjected to various evaluation tests such as in-vitro drug release and ex-vivo intestinal permeation study. Conclusion: Liquisolid technology was found to be promising due to enhance solubility, dissolution and permeation of candesartan cilexetil by 19.75, 3.09 and 2.4-fold, respectively.
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Article metadata
| Title | Liquisolid Compact Tablet of Candesartan Cilexetil with Enhanced Solubility using Neusilin US2, Aerosil 200 and Transcutol HP |
|---|---|
| Authors | Pallavi Argade; Vinita Chandrakant Patole; Ashlesha Pravin Pandit |
| Affiliations | Department of Pharmaceutics, JSPM Rajarshi Shahu College of Pharmacy and Research, Tathawade, Pune, Maharashtra, INDIA. |
| Corresponding author | panditashleshap@rediffmail.com |
| Journal | Indian Journal of Pharmaceutical Education and Research |
| Volume / Issue | Vol. 53, Issue 3 (2019) |
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