Open access · Peer reviewed · No APCs
Original ArticleIndian Journal of Pharmaceutical Education and ResearchVol. 53 | Issue 4 | 2019 | pp. 670–674Open access
In vitro Anti-atherothrombosis Activity of Nigella sativa Oil, Phytol and their Combinations
- 1,2*,
- 3,
- 3,
- 3,
- 3
- 1 Department for Management of Science and Technology Development, Ton Duc Thang University, Ho Chi Minh City-700000, VIETNAM.
- 2 Faculty of Pharmacy, Ton Duc Thang University, Ho Chi Minh City-700000, VIETNAM.
- 3 Department of Pharmacy, Life Science Faculty, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj (Dhaka)-8100, BANGLADESH.
Published in Indian Journal of Pharmaceutical Education and Research
Correspondence: Muhammad Torequl Islam
Department for Management of Science and Technology Development, Ton Duc Thang University, Ho Chi Minh City-700000, VIETNAM.; Faculty of Pharmacy, Ton Duc Thang University, Ho Chi Minh City-700000, VIETNAM.
Email: muhammad.torequl.islam@tdtu.edu.vn
Copyright: © 2019 Manuscript Technomedia. This is an open access article.
- Published:
- Sep 18, 2019
- Received:
- Feb 22, 2019
- Accepted:
- Sep 4, 2019
How to cite
Islam, M. T., Molla, S., Das, A. K., Zaman, F., & Khan, M. R. (2019). In vitro Anti-atherothrombosis Activity of Nigella sativa Oil, Phytol and their Combinations. Indian Journal of Pharmaceutical Education and Research, 53(4), 670–674. https://doi.org/10.5530/ijper.53.4.129
Abstract
Background: Black seed oil and Phytol (PHY) are evident for their promising biological effects in various test systems. Aim: This study evaluates anti-atherothrombosis activity of Nigella sativa oil (NSO) and Phytol (PHY). Materials and Methods: The clotlysis activity of the NSO and/or PHY has been investigated by taking Streptokinase (SK) as a standard clotlysis drug. Results: The results suggest that the NSO and PHY exhibited a concentration-dependent clotlysis activity in human clotted blood. The highest clotlysis of the NSO and PHY was seen by 57.83 ± 0.23% and 53.05 ± 2.93% with 80 µL and 150 µg per tube, respectively. NSO co-treated with PHY showed a better clotlysis capacity than the NSO and PHY. The vehicle showed negligible clotlysis (2.86 ± 4.33%) capacity, while the standard SK (100 I.U.) showed 78.96 ± 1.08% clotlysis activity. Conclusion: NSO and/or PHY exhibited clotlysis activity in human clotted blood in in vitro.
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Article metadata
| Title | In vitro Anti-atherothrombosis Activity of Nigella sativa Oil, Phytol and their Combinations |
|---|---|
| Authors | Muhammad Torequl Islam; Shamim Molla; Apu Kumar Das; Farhana Zaman; Md. Roich Khan |
| Affiliations | Department for Management of Science and Technology Development, Ton Duc Thang University, Ho Chi Minh City-700000, VIETNAM.; Faculty of Pharmacy, Ton Duc Thang University, Ho Chi Minh City-700000, VIETNAM.; Department of Pharmacy, Life Science Faculty, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj (Dhaka)-8100, BANGLADESH. |
| Corresponding author | muhammad.torequl.islam@tdtu.edu.vn |
| Journal | Indian Journal of Pharmaceutical Education and Research |
| Volume / Issue | Vol. 53, Issue 4 (2019) |
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