Open access · Peer reviewed · No APCs
Review ArticleIndian Journal of Pharmaceutical Education and ResearchVol. 53 | Issue 4s | 2019 | pp. s475–s480Open access
Recent Advancements in Spectrophotometric pKa Determinations: A Review
- 1,
- 2*
- 1 Faculty of Science, Radboud University, Nijmegen, NETHERLANDS.
- 2 Department of Pharmacognosy, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, INDIA.
Published in Indian Journal of Pharmaceutical Education and Research
Correspondence: Aswatha Ram HN
Department of Pharmacognosy, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, INDIA.
Email: aswatharam@gmail.com
Copyright: © 2019 Manuscript Technomedia. This is an open access article.
- Published:
- Nov 18, 2019
- Received:
- Feb 22, 2019
- Accepted:
- Sep 14, 2019
How to cite
Berkhout, J. H., & HN, A. R. (2019). Recent Advancements in Spectrophotometric pKa Determinations: A Review. Indian Journal of Pharmaceutical Education and Research, 53(4s), s475–s480. https://doi.org/10.5530/ijper.53.4s.141
Abstract
The pKa value is a key feature in Absorption, Distribution, Metabolism and Excretion (ADME) of drugs, thus knowing this value is critical in drug development. In this review, pKa values determined in the past decade, using UV-Vis spectrometry, are discussed. To determine the pKa, four methods were applied; Henderson-Hasselbach, Albert-Serjeant, Bates-Schwarzenbach and Spectrometric titrations. This review will show the value of this aged but well-established technique in the past decade, due to its simplicity, accuracy, cost efficiency and reproducibility.
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Article metadata
| Title | Recent Advancements in Spectrophotometric pKa Determinations: A Review |
|---|---|
| Authors | Job Herman Berkhout; Aswatha Ram HN |
| Affiliations | Faculty of Science, Radboud University, Nijmegen, NETHERLANDS.; Department of Pharmacognosy, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, INDIA. |
| Corresponding author | aswatharam@gmail.com |
| Journal | Indian Journal of Pharmaceutical Education and Research |
| Volume / Issue | Vol. 53, Issue 4s (2019) |
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