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Original ArticleIndian Journal of Pharmaceutical Education and ResearchVol. 54 | Issue 2 | 2020 | pp. 448–455Open access
Quantitative Analysis of Pantoprazole Sodium Sesquihydrate in Bulk and Solid Dosage Form via UV-Spectrophotometric Method
- 1,
- 1,
- 1,
- 2,
- 3,4*
- 1 Faculty of Pharmacy, Jinnah University for Women, Karachi, PAKISTAN.
- 2 Institute of Pharmaceutical Sciences, Jinnah Sindh Medical University, Karachi, PAKISTAN.
- 3 Research Laboratories Centre, Faculty of Applied Sciences, Umm Al Qura University, Makkah, SAUDI ARABIA.
- 4 Department of Chemistry, Faculty of Applied Sciences, Umm Al Qura University, Makkah, SAUDI ARABIA.
Published in Indian Journal of Pharmaceutical Education and Research
Correspondence: Agha Zeeshan Mirza
Research Laboratories Centre, Faculty of Applied Sciences, Umm Al Qura University, Makkah, SAUDI ARABIA.; Department of Chemistry, Faculty of Applied Sciences, Umm Al Qura University, Makkah, SAUDI ARABIA.
Email: drsomi1983@yahoo.com
Copyright: © 2020 Manuscript Technomedia. This is an open access article.
- Published:
- Mar 12, 2020
- Received:
- Jul 20, 2019
- Accepted:
- Dec 23, 2019
How to cite
Rafiq, A., Gul, S., Ajaz, A., Fatima, S., & Mirza, A. Z. (2020). Quantitative Analysis of Pantoprazole Sodium Sesquihydrate in Bulk and Solid Dosage Form via UV-Spectrophotometric Method. Indian Journal of Pharmaceutical Education and Research, 54(2), 448–455. https://doi.org/10.5530/ijper.54.2.51
Abstract
Pantoprazole sodium sesquihydrate, is a proton pump inhibitor, was analyzed by using UV spectrophotometry. The quantification of pantoprazole sodium sesquihydrate in distilled water was performed in the wavelength range of 290 nm at 20 μgmL-1. The linearity range is 5-35 μgmL-1 by using UV spectrophotometry. The developed method was applied directly and easily to the analysis of the pantoprazole sodium sesquihydrate in bulk and pharmaceutical tablet preparations. The developed method was completely validated according to ICH guidelines. The accuracy of the developed method was calculated in terms of percentage recovery (99.20-101.21%) and %RSD values less than 1% were found in precision. The LOD and LOQ were 0.989 and 1.954 μgmL-1, respectively. Because of simplicity, accuracy and cost-effectiveness, this validated method is helpful for a daily laboratory analysis of pantoprazole sodium sesquihydrate.
Keywords
Subject
Article metadata
| Title | Quantitative Analysis of Pantoprazole Sodium Sesquihydrate in Bulk and Solid Dosage Form via UV-Spectrophotometric Method |
|---|---|
| Authors | Asma Rafiq; Somia Gul; Arzoo Ajaz; Sakina Fatima; Agha Zeeshan Mirza |
| Affiliations | Faculty of Pharmacy, Jinnah University for Women, Karachi, PAKISTAN.; Institute of Pharmaceutical Sciences, Jinnah Sindh Medical University, Karachi, PAKISTAN.; Research Laboratories Centre, Faculty of Applied Sciences, Umm Al Qura University, Makkah, SAUDI ARABIA.; Department of Chemistry, Faculty of Applied Sciences, Umm Al Qura University, Makkah, SAUDI ARABIA. |
| Corresponding author | drsomi1983@yahoo.com |
| Journal | Indian Journal of Pharmaceutical Education and Research |
| Volume / Issue | Vol. 54, Issue 2 (2020) |
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