Open access · Peer reviewed · No APCs
Original ArticleIndian Journal of Pharmaceutical Education and ResearchVol. 55 | Issue 1 | 2021 | pp. 117–125Open access
Doxorubicin Hydrochloride Loaded Polyanhydride Nanoformulations and Cytotoxicity
- 1,2*,
- 3,
- 4,
- 5,
- 6,
- 7,
- 1,
- 1,
- 1,
- 1,8
- 1 Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, SAUDI ARABIA.
- 2 Department of Pharmaceutics, Vidya Siri College of Pharmacy, Off Sarjapura Road, Bangalore, Karnataka, INDIA.
- 3 Department of Pharmaceutics, PA College of Pharmacy, Mangalore, Karnataka, India.
- 4 Department of Pharmaceutics, East West College of Pharmacy, Bangalore, Karnataka, INDIA.
- 5 Department of Biomedical Sciences, College of Medicine, King Faisal University, Al-Ahsa, SAUDI ARABIA.
- 6 Department of Pharmacognosy, PA College of Pharmacy, Mangalore, Karnataka, INDIA.
- 7 Department of Chemistry, College of Science, King Faisal University, Hofuf, SAUDI ARABIA.
- 8 Department of Biotechnology and Food Technology, Durban University of Technology, Durban, SOUTH AFRICA.
Published in Indian Journal of Pharmaceutical Education and Research
Correspondence: Nagaraja Sreeharsha
Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, SAUDI ARABIA.; Department of Pharmaceutics, Vidya Siri College of Pharmacy, Off Sarjapura Road, Bangalore, Karnataka, INDIA.
Email: sharsha@kfu.edu.sa
Copyright: © 2021 Manuscript Technomedia. This is an open access article.
- Published:
- Jan 15, 2021
- Received:
- Jul 14, 2020
- Accepted:
- Oct 1, 2020
- DOI:
- 10.5530/ijper.55.1.2
How to cite
Sreeharsha, N., Hiremath, J. G., R, P. K., Meravanige, G., Khan, S., Karnati, R. K., Attimarad, M., Al-Dhubiab, B., Nair, A. B., & Venugopala, K. N. (2021). Doxorubicin Hydrochloride Loaded Polyanhydride Nanoformulations and Cytotoxicity. Indian Journal of Pharmaceutical Education and Research, 55(1), 117–125. https://doi.org/10.5530/ijper.55.1.2
Abstract
This study aimed to evaluate DOX∙HCl loaded P(DLLA-CO:60:40) nanoformulations with a copolymer of F127 as a potential drug delivery system for cancer. DOX ∙ HCl was encapsulated in nanoformulations of Poly DL-lactic acid co castor oil 60:40, P(DLLACO: 60:40) polymer with the copolymer/stabilizer Pluronic® F127. The mean diameter of the cylindrical rod shape of the nanoformulation particles was 248±2.4-260±3.2 nm with an acceptable poly dispersibility of 0.29- 0.33 and a smooth surface as visualized by DSC, SEM and XRD displayed that DOX∙HCl was present as an disordered crystalline or amorphous state in the nanoformulations. The nanoformulations showed a steady pattern of drug discharge for 24 hrs. F-3 and F-4 formulations had IC50 values of 3.2±0.03 and 1.98±0.08 mcg/ml while the free drug inhibition concentration of IC50 was 2.2 mcg/ml. The drug-loaded nanoformulations showed significant cytotoxic effects on MCF-7 breast cancer cell lines.
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Article metadata
| Title | Doxorubicin Hydrochloride Loaded Polyanhydride Nanoformulations and Cytotoxicity |
|---|---|
| Authors | Nagaraja Sreeharsha; Jagadeesh G Hiremath; Prashanth Kumar R; Girish Meravanige; Saleemulla Khan; Ranjith Kumar Karnati; Mahesh Attimarad; Bandar Al-Dhubiab; Anroop Balachandran Nair; Katharigatta Narayanaswamy Venugopala |
| Affiliations | Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, SAUDI ARABIA.; Department of Pharmaceutics, Vidya Siri College of Pharmacy, Off Sarjapura Road, Bangalore, Karnataka, INDIA.; Department of Pharmaceutics, PA College of Pharmacy, Mangalore, Karnataka, India.; Department of Pharmaceutics, East West College of Pharmacy, Bangalore, Karnataka, INDIA.; Department of Biomedical Sciences, College of Medicine, King Faisal University, Al-Ahsa, SAUDI ARABIA.; Department of Pharmacognosy, PA College of Pharmacy, Mangalore, Karnataka, INDIA.; Department of Chemistry, College of Science, King Faisal University, Hofuf, SAUDI ARABIA.; Department of Biotechnology and Food Technology, Durban University of Technology, Durban, SOUTH AFRICA. |
| Corresponding author | sharsha@kfu.edu.sa |
| Journal | Indian Journal of Pharmaceutical Education and Research |
| Volume / Issue | Vol. 55, Issue 1 (2021) |
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