Development and Characterization of Cinnamon Oil- Salicylic Acid Blended Nanoemulsion (CSN) for topical Application

Background: This study aimed to develop and describe a Cinnamon Oil-Salicylic Acid Blended Nanoemulsion (CSN) for topical use. Different ratios of oil, surfactants, and water were used to create the base for the nanoemulsions. Methods: To determine the nanoemulsion (NE) base regions, pseudo ternary phase diagrams were created. In addition, nine formulations containing mixes of Tween 80 and ethanol were examined for their droplet size, zeta potential, viscosity, pH, microscopy and spectroscopic technique. Results: As a result of the experiments, it was discovered that the nanoemulsion comprising cinnamon oil and salicylic acid had an average size of 103.55 ± 1.83 and excellent rheological properties. Results revealed that the nanoemulsion bases, including ethanol as a co-surfactant, produced a larger emulsion area in the phase diagram than the other nanoemulsion bases. The formulation exhibited homogeneity, stability, and viscosity. Spherical NE was observed in transmission electron microscopy photos of CSN, and the size distribution was very narrow. The results of the in vitro release investigation showed that the medicine was released at a 95.87% effective rate in 24 hr. At a temperature of 25°C, the results of the short-term stability research, which was carried out for six months, revealed that CSN is stable. When applied to the skin of animals, CSN showed no signs of skin toxicity or irritation. Conclusion: As a result, CSN is an excellent natural-based preparation that may be utilized topically against different kinds of skin conditions.