Brassinin Exhibits Anti-Diabetic Activity against Streptozotocin-induced Diabetes Mellitus in Experimental Rats

Xu, Bixia; Alarfaj, Abdullah A.; Hirad, Abdurahman Hajinur; Natarajan, Nandakumar; Iyappan, Petchi; Al Ali, Samer Hasan Hussein

doi:10.5530/ijper.57.3s.79

Original ArticleIndian Journal of Pharmaceutical Education and ResearchVol. 57 | Issue 3s | 2023 | pp. s701–s709Open access

Brassinin Exhibits Anti-Diabetic Activity against Streptozotocin-induced Diabetes Mellitus in Experimental Rats

¹^*,
²,
²,
³,
⁴,
⁵

¹ Teaching and Research Section of Internal Medicine, Zhaoqing Medical College, Guangdong Province, CHINA.
² Department of Botany and Microbiology, College of Science, King Saud University, Riyadh, SAUDI ARABIA.
³ Department of Cellular and Molecular Biology, University of Texas at Tyler Health Science Center, Tyler, TEXAS, USA.
⁴ Faculty of Medicine, Bioscience and Nursing, Mahsa University, Saujana Putra, MALAYSIA.
⁵ Department of Chemistry, Faculty of Science, Isra University, Amman, JORDAN.

Correspondence: Bixia Xu
Teaching and Research Section of Internal Medicine, Zhaoqing Medical College, Guangdong Province, CHINA.
Email: surither@hotmail.com

Published:: Jul 15, 2023
Received:: Jan 1, 2023
Accepted:: Jul 1, 2023
DOI:: 10.5530/ijper.57.3s.79

How to cite

Xu, B., Alarfaj, A. A., Hirad, A. H., Natarajan, N., Iyappan, P., & Ali, S. H. H. A. (2023). Brassinin Exhibits Anti-Diabetic Activity against Streptozotocin-induced Diabetes Mellitus in Experimental Rats. Indian Journal of Pharmaceutical Education and Research, 57(3s), s701–s709. https://doi.org/10.5530/ijper.57.3s.79

Abstract

Background: Diabetes mellitus is among the most serious public health problems worldwide. Materials and Methods: 35mg/kg STZ was injected to rats for stimulating diabetes. Then rats were treated with 25mg/kg of brassinin. Results: Brassinin and Glibenclamide remarkably decreased glucose and HbA1c levels in diabetic rats, while insulin levels were elevated. They also increased antioxidant enzymes and decreased inflammatory markers. Conclusion: Brassinin is an antihyperglycemic, antioxidant, and anti-inflammatory compound that protects the liver, kidney, and pancreas during diabetes.

Keywords

Article metadata

Title	Brassinin Exhibits Anti-Diabetic Activity against Streptozotocin-induced Diabetes Mellitus in Experimental Rats
Authors	Bixia Xu; Abdullah A. Alarfaj; Abdurahman Hajinur Hirad; Nandakumar Natarajan; Petchi Iyappan; Samer Hasan Hussein Al Ali
Affiliations	Teaching and Research Section of Internal Medicine, Zhaoqing Medical College, Guangdong Province, CHINA.; Department of Botany and Microbiology, College of Science, King Saud University, Riyadh, SAUDI ARABIA.; Department of Cellular and Molecular Biology, University of Texas at Tyler Health Science Center, Tyler, TEXAS, USA.; Faculty of Medicine, Bioscience and Nursing, Mahsa University, Saujana Putra, MALAYSIA.; Department of Chemistry, Faculty of Science, Isra University, Amman, JORDAN.
Corresponding author	surither@hotmail.com
Journal	Indian Journal of Pharmaceutical Education and Research
Volume / Issue	Vol. 57, Issue 3s (2023)