In vitro and in vivo Antidiabetic Activity of Ag Nanoparticles Mediated from Gymnemic Acid I and II

Sivaramakumar, Navanita; Shanker, Kalakotla

doi:10.5530/ijper.57.3s.80

Original ArticleIndian Journal of Pharmaceutical Education and ResearchVol. 57 | Issue 3s | 2023 | pp. s710–s717Open access

In vitro and in vivo Antidiabetic Activity of Ag Nanoparticles Mediated from Gymnemic Acid I and II

¹,
¹^*

¹ Department of Pharmacognosy, JSS College of Pharmacy, Ooty, Nilgiris, Tamil Nadu, INDIA.

Correspondence: Kalakotla Shanker
Department of Pharmacognosy, JSS College of Pharmacy, Ooty, Nilgiris, Tamil Nadu, INDIA.
Email: shankerkalakotla@gmail.com

Published:: Jul 15, 2023
Received:: Aug 27, 2022
Accepted:: Jun 8, 2023
DOI:: 10.5530/ijper.57.3s.80

How to cite

Sivaramakumar, N., & Shanker, K. (2023). In vitro and in vivo Antidiabetic Activity of Ag Nanoparticles Mediated from Gymnemic Acid I and II. Indian Journal of Pharmaceutical Education and Research, 57(3s), s710–s717. https://doi.org/10.5530/ijper.57.3s.80

Abstract

Background: Gymnema sylvestre is traditionally used to treat diabetes in Asia. Materials and methods: GA-I and GA-II were docked to PTP 1B. Nanoparticles were produced using centrifugation green synthesis. Results: Blood glucose levels significantly decreased (p less than 0.001) at a dose of 200 mg/kg of GA-I mediated AgNPs. Conclusion: GA-I mediated AgNPs can be exploited as prospective nanomedicine for type-2 diabetes.

Keywords

Article metadata

Title	In vitro and in vivo Antidiabetic Activity of Ag Nanoparticles Mediated from Gymnemic Acid I and II
Authors	Navanita Sivaramakumar; Kalakotla Shanker
Affiliations	Department of Pharmacognosy, JSS College of Pharmacy, Ooty, Nilgiris, Tamil Nadu, INDIA.
Corresponding author	shankerkalakotla@gmail.com
Journal	Indian Journal of Pharmaceutical Education and Research
Volume / Issue	Vol. 57, Issue 3s (2023)