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research-articleIndian Journal of Pharmaceutical Education and ResearchVol. 58 | Issue 3 | 2024 | pp. 830–836Open access
Anticancer and Hepatoprotective Role of Selenium Nanoparticles against Liver Carcinogen Acrylamide Induced Toxicity: In vitro and in vivo Studies
- 1*,
- 1,2,
- 3,4,
- 5,6,
- 1,
- 7,
- 1,8,
- 9
- 1 Department of Biochemistry, University of Tabuk, Tabuk, SAUDI ARABIA.
- 2 Department of Home Economics, Faculty of Specific Education, Kafr ElShaikh University, Kafr El-Sheikh Governorate, EGYPT.
- 3 Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Tabuk, Tabuk, SAUDI ARABIA.
- 4 Department of Biochemistry, Faculty of Pharmacy, Zagazig University, Zagazig, EGYPT.
- 5 Department of Biology, University of Tabuk, Tabuk, SAUDI ARABIA.
- 6 Department of Biology, Faculty of Science, Ibb University, Ibb, YEMEN.
- 7 Biotechnology Divisions, CSIR-Central Institute of Medicinal and Aromatic Plants, Lucknow, Uttar Pradesh, INDIA.
- 8 Department of Chemistry, Faculty of Sciences, Tanta University, Tanta, EGYPT.
- 9 Department of Chemistry, University of Tabuk, Tabuk, SAUDI ARABIA.
Published in Indian Journal of Pharmaceutical Education and Research
Correspondence: Uzma Faridi
Department of Biochemistry, University of Tabuk, Tabuk, SAUDI ARABIA.
Email: ufaridi@ut.edu.sa
Copyright: © 2024 Manuscript Technomedia. This is an open access article.
- Published:
- Jun 21, 2024
- Received:
- Sep 12, 2023
- Accepted:
- Mar 9, 2024
How to cite
Faridi, U., Zidan, N., Atteia, H., Al-Awthan, Y., Alalawy, A. I., Akhtar, M. Q., Sakran, M., & Parveen, H. (2024). Anticancer and Hepatoprotective Role of Selenium Nanoparticles against Liver Carcinogen Acrylamide Induced Toxicity: In vitro and in vivo Studies. Indian Journal of Pharmaceutical Education and Research, 58(3), 830–836. https://doi.org/10.5530/ijper.58.3.91
Abstract
Background and Objectives
Selenium is considered one of the essential components of many enzymes, particularly the antioxidant enzymes such as thioredoxin reductase. Vegetables, among other food sources, are common sources of selenium. In the present study, the green synthesis of Selenium nanoparticles (SeNPs) from Ocimum basilicum’ aerial part was carried out, as were the anticancer and hepatoprotective roles of selenium nanoparticles against liver carcinogen acrylamide-induced toxicity.
Materials and Methods
The classification of SeNPs was done by different spectroscopic methods, including UV-spectroscopy, FT-IR, XRD, and HR-TEM. The synthesized SeNPs were tested for their anticancer properties using MTT assays (the normal human liver fibroblast cell line (WISH) and Human liver cancer (HepG2), respectively).
Results
The histopathological studies indicated that the liver acrylamide induced in mice showed necrosis and damage in liver cells, but the treatment of mice with SeNPs, reduced the effect of acrylamide significantly.
Conclusion
The results indicated the protective effect of SeNPs on acrylamide-induced cells both in vitro and in vivo.
Keywords
Article metadata
| Title | Anticancer and Hepatoprotective Role of Selenium Nanoparticles against Liver Carcinogen Acrylamide Induced Toxicity: In vitro and in vivo Studies |
|---|---|
| Authors | Uzma Faridi; Nahla Zidan; Hebbatallah Atteia; Yahya Al-Awthan; Adel I Alalawy; Md. Qussen Akhtar; Mohamed Sakran; Humaira Parveen |
| Affiliations | Department of Biochemistry, University of Tabuk, Tabuk, SAUDI ARABIA.; Department of Home Economics, Faculty of Specific Education, Kafr ElShaikh University, Kafr El-Sheikh Governorate, EGYPT.; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Tabuk, Tabuk, SAUDI ARABIA.; Department of Biochemistry, Faculty of Pharmacy, Zagazig University, Zagazig, EGYPT.; Department of Biology, University of Tabuk, Tabuk, SAUDI ARABIA.; Department of Biology, Faculty of Science, Ibb University, Ibb, YEMEN.; Biotechnology Divisions, CSIR-Central Institute of Medicinal and Aromatic Plants, Lucknow, Uttar Pradesh, INDIA.; Department of Chemistry, Faculty of Sciences, Tanta University, Tanta, EGYPT.; Department of Chemistry, University of Tabuk, Tabuk, SAUDI ARABIA. |
| Corresponding author | ufaridi@ut.edu.sa |
| Journal | Indian Journal of Pharmaceutical Education and Research |
| Volume / Issue | Vol. 58, Issue 3 (2024) |
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