Open access · Peer reviewed · No APCs
Review ArticleIndian Journal of Pharmaceutical Education and ResearchVol. 59 | Issue 2 | 2025 | pp. 453–471Open access
Deciphering Molecular Insights into Isocitrate Lyase and their Inhibitors: A Detailed Display through Medicinal Chemistry Window
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- 1 Department of Pharmaceutical Chemistry, BVDU's Poona College of Pharmacy, Paud Road, Erandwane, Pune, Maharashtra, INDIA.
- 2 Department of Pharmacology, BVDU's Poona College of Pharmacy, Paud Road, Erandawane, Pune,, Maharashtra, INDIA.
- 3 Department of Pharmaceutical Chemistry, UCPSc, Kakatiya University, Warangal, Telangana, INDIA.
- 4 Department of Pharmacognosy, BVDU's Poona College of Pharmacy, Paud Road, Erandawane, Pune,, Maharashtra, INDIA.
- 5 Department of Entomology, University of California, Davis, One Shields Ave, Davis, California, USA.
- 6 UC Davis Comprehensive Cancer Centre, University of California, Davis, One Shields Ave, Davis, California, USA.
Published in Indian Journal of Pharmaceutical Education and Research
Correspondence: Gritika Khanojia
Department of Pharmaceutical Chemistry, BVDU's Poona College of Pharmacy, Paud Road, Erandwane, Pune, Maharashtra, INDIA.
Email: ravigk2000@gmail.com
Copyright: © 2025 Manuscript Technomedia. This is an open access article.
- Published:
- Mar 6, 2025
- Received:
- Sep 3, 2023
- Accepted:
- Jan 22, 2025
How to cite
Khanojia, G., Walhekar, V., Ashwini, P., Birajdar, P., Ritesh, P., Muthal, A., Bodhankar, S., Bagul, C., Kumar, D., Macha, B., Shinde, V., & Kulkarni, R. (2025). Deciphering Molecular Insights into Isocitrate Lyase and their Inhibitors: A Detailed Display through Medicinal Chemistry Window. Indian Journal of Pharmaceutical Education and Research, 59(2), 453–471. https://doi.org/10.5530/ijper.20255143
Abstract
Aim
Isocitrate lyase is the ancient glyoxylate cycle enzyme that catalyzes isocitrate cleavage into succinate and glyoxylate. The glyoxylate cycle is a key metabolic pathway as indicated by significant data on many host pathogens, which confirm the fundamental existence, in particular, causing life-threatening diseases, including tuberculosis.
Objectives
Mycobacterium tuberculosis Isocitrate lyase and other organisms, which express ICL, have attracted the attention of molecular biologists and medicinal chemists due to their indispensable role in normal cellular metabolic pathways and even resistance. Numerous studies that blocked genes expressing ICL and gene knockout in experimental animals indicated retarded growth. The origins of these inhibitor studies approaches are categorized into mycobacterial and non-mycobacterial Isocitrate lyases.
Conclusion
Nonetheless, these inhibitors can be either synthetic or natural, while in this study, the authors emphasize catalytic enzyme information of Isocitrate lyase.
Keywords
Subject
Article metadata
| Title | Deciphering Molecular Insights into Isocitrate Lyase and their Inhibitors: A Detailed Display through Medicinal Chemistry Window |
|---|---|
| Authors | Gritika Khanojia; Vinayak Walhekar; Patil Ashwini; Pratik Birajdar; Pawar Ritesh; Amol Muthal; Subhash Bodhankar; Chandrakant Bagul; Dileep Kumar; Baswaraju Macha; Vaibhav Shinde; Ravindra Kulkarni |
| Affiliations | Department of Pharmaceutical Chemistry, BVDU's Poona College of Pharmacy, Paud Road, Erandwane, Pune, Maharashtra, INDIA.; Department of Pharmacology, BVDU's Poona College of Pharmacy, Paud Road, Erandawane, Pune,, Maharashtra, INDIA.; Department of Pharmaceutical Chemistry, UCPSc, Kakatiya University, Warangal, Telangana, INDIA.; Department of Pharmacognosy, BVDU's Poona College of Pharmacy, Paud Road, Erandawane, Pune,, Maharashtra, INDIA.; Department of Entomology, University of California, Davis, One Shields Ave, Davis, California, USA.; UC Davis Comprehensive Cancer Centre, University of California, Davis, One Shields Ave, Davis, California, USA. |
| Corresponding author | ravigk2000@gmail.com |
| Journal | Indian Journal of Pharmaceutical Education and Research |
| Volume / Issue | Vol. 59, Issue 2 (2025) |
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