Open access · Peer reviewed · No APCs
Review ArticleIndian Journal of Pharmaceutical Education and ResearchVol. 58 | Issue 1s | 2024 | pp. s58–s66Open access
Molecular Insights into Salicylate Synthase: From Medicinal Chemistry Perspective
- 1,
- 1,
- 1,
- 1,
- 2,
- 2,
- 1,
- 1,5,6,
- 3,
- 4,
- 7,
- 1*
- 1 Department of Pharmaceutical Chemistry, BVDU’S Poona College of Pharmacy, Erandwane Pune, Maharashtra, INDIA.
- 2 Department of Pharmacology, BVDU’s Poona College of Pharmacy, Paudh Road, Erandawane, Pune, Maharashtra, INDIA.
- 3 Department of Pharmaceutical Chemistry, UCPSc, Kakatiya University, Warangal, Telangana, INDIA.
- 4 Department of Pharmaceutics, Sri Sanganabasava Mahaswamiji College of Pharmacy and Research Center, Vijayapura, Karnataka, INDIA.
- 5 Department of Entomology, University of California, Davis, One Shields Ave, Davis, CA, USA.
- 6 UC Davis Comprehensive Cancer Centre, University of California, Davis, One Shields Ave, Davis, CA, USA.
- 7 Department of Pharmacognosy, BVDU’s Poona College of Pharmacy, Paud Road, Erandawane, Pune, Maharashtra, INDIA.
Published in Indian Journal of Pharmaceutical Education and Research
Correspondence: Ravindra Kulkarni
Department of Pharmaceutical Chemistry, BVDU’S Poona College of Pharmacy, Erandwane Pune, Maharashtra, INDIA.
Email: ravigk2000@gmail.com
Copyright: © 2024 Manuscript Technomedia. This is an open access article.
- Published:
- Jan 12, 2024
- Received:
- Jan 25, 2023
- Accepted:
- Nov 3, 2023
How to cite
Bire, N., Walhekar, V., Makane, O., Yelchatwar, P., Muthal, A., Bodhankar, S., Bagul, C., Kumar, D., Macha, B., Kulkarni, R., Shinde, V., & Kulkarni, R. (2024). Molecular Insights into Salicylate Synthase: From Medicinal Chemistry Perspective. Indian Journal of Pharmaceutical Education and Research, 58(1s), s58–s66. https://doi.org/10.5530/ijper.58.1s.5
Abstract
Tuberculosis is a pathogenic infection that has created trepidation around the globe due to its repercussion on the health of patients. The iron transport mechanism in mycobacterium plays a pivotal role in bacterial survival; whilst this can be considered an emerging drug target. Salicylate synthase is a member of the MST family and this enzyme is distrait in mammals. It is the first enzyme for the synthesis of mycobactin (siderophores) which is a determinant for iron transport. The present all-embracing review provides overall coverage of the biological and structural outlook of the enzyme salicylate synthase and its inhibitors reported in recent years. Furthermore, this review sheds limelight on the development of novel and more potent salicylate synthase inhibitors.
Keywords
Subject
Article metadata
| Title | Molecular Insights into Salicylate Synthase: From Medicinal Chemistry Perspective |
|---|---|
| Authors | Nitin Bire; Vinayak Walhekar; Omkar Makane; Pranali Yelchatwar; Amol Muthal; Subhash Bodhankar; Chandrakant Bagul; Dileep Kumar; Baswaraju Macha; Raghavendra Kulkarni; Vaibhav Shinde; Ravindra Kulkarni |
| Affiliations | Department of Pharmaceutical Chemistry, BVDU’S Poona College of Pharmacy, Erandwane Pune, Maharashtra, INDIA.; Department of Pharmacology, BVDU’s Poona College of Pharmacy, Paudh Road, Erandawane, Pune, Maharashtra, INDIA.; Department of Pharmaceutical Chemistry, UCPSc, Kakatiya University, Warangal, Telangana, INDIA.; Department of Pharmaceutics, Sri Sanganabasava Mahaswamiji College of Pharmacy and Research Center, Vijayapura, Karnataka, INDIA.; Department of Entomology, University of California, Davis, One Shields Ave, Davis, CA, USA.; UC Davis Comprehensive Cancer Centre, University of California, Davis, One Shields Ave, Davis, CA, USA.; Department of Pharmacognosy, BVDU’s Poona College of Pharmacy, Paud Road, Erandawane, Pune, Maharashtra, INDIA. |
| Corresponding author | ravigk2000@gmail.com |
| Journal | Indian Journal of Pharmaceutical Education and Research |
| Volume / Issue | Vol. 58, Issue 1s (2024) |
Also in this issue
- Quality Concerns of Lip Care Cosmetics and Applicable Regulatory Framework: Need for a Harmonized Cosmetovigilance Programmepp. s1–s8
- Role of Social Media for Drug Safety Signal Detectionpp. s9–s25
- Heterocyclic Compounds and their Derivatives with Potential Anticancer Activitypp. s26–s39
- Insight into the Regulation of Nrf2/Keap 1 Pathway by Flavonoids as an Approach for Treatment of Liver Diseases: A Reviewpp. s40–s57
- Synthesis and Bioactive Investigation of Amino Acids Fused 1,3,4-Oxadiazole Derivatives as Unnatural Amino Acidspp. s67–s72
Readers Also Viewed
Development and Validation of UV/visible Spectrophotometric Method for Estimation of Piroxicam from Bulk and Formulation
Sandip Mohan Honmane, Kunal Rajaram Yadav, Yuvraj Dilip Dange
Apr 23, 2025
Effects of Artificial Intelligence on Academic Performance of Library and Information Science University Students: A Meta-Analysis (2023-2025)
Kayode Sunday John Dada
Aug 6, 2026
Bridging Innovation and Impact: A Multidisciplinary Approach to Contemporary Research Challenges
Mueen Ahmed KK
Aug 11, 2026