Open access · Peer reviewed · No APCs
Original ArticleIndian Journal of Pharmaceutical Education and ResearchVol. 59 | Issue 2 | 2025 | pp. 602–616Open access
Formulation, Characterization and in vivo Evaluation of 5-Fluorouracil-Loaded Polymeric Micelles for Non-Melanoma Skin Cancer
- 1*,
- 1*,
- 2*,
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- 1*,
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- 1 M.M. College of Pharmacy, Maharishi Markandeshwar (Deemed to be University), Mullana, Ambala, Haryana, INDIA.
- 2 Department of Pharmaceutics, ISF College of Pharmacy, Moga, Punjab, INDIA.
- 3 Department of Anesthesia Technology, College of Applied Medical Sciences in Jubail, Imam Abdul Rahman Bin Faisal University, Jubail, SAUDI ARABIA.
- 4 Department of Biomedical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, SAUDI ARABIA.
- 5 Department of Pharmaceutical Sciences, College of Pharmacy, Gulf Medical University, Ajman, UNITED ARAB EMIRATES.
- 6 Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, SAUDI ARABIA.
Published in Indian Journal of Pharmaceutical Education and Research
Correspondence: Navneet Mehan
M.M. College of Pharmacy, Maharishi Markandeshwar (Deemed to be University), Mullana, Ambala, Haryana, INDIA.
Email: vipinsaini31@rediffmail.com
Copyright: © 2025 Manuscript Technomedia. This is an open access article.
- Published:
- Mar 6, 2025
- Received:
- Jul 2, 2024
- Accepted:
- Feb 12, 2025
How to cite
Mehan, N., Saini, V., Manish, K., Goyal, M., Devi, S., Pottathil, S., Jacob, S., & Nair, A. B. (2025). Formulation, Characterization and in vivo Evaluation of 5-Fluorouracil-Loaded Polymeric Micelles for Non-Melanoma Skin Cancer. Indian Journal of Pharmaceutical Education and Research, 59(2), 602–616. https://doi.org/10.5530/ijper.20251736
Abstract
Background
The goal of the study was to evaluate the prospective of fluorouracil-loaded polymeric micelles for topical delivery in non-melanoma skin cancer.
Materials and Methods
Polymeric micelles were developed by thin film hydration technique and characterized for physico-chemical properties, in vitro drug release, ex vivo skin penetration as well as in vivo skin irritation and anticancer effect.
Results
Preliminary studies were carried out in twelve Formulations (FM1-FM12) and the Formulation (FM4) with the highest entrapment efficiency (~95%) and greater drug release (~98%) was developed into gels (FG1-FG5). The selected gel Formulation (FG4) exhibited adequate viscosity (~5000 cP), ideal pH (~6.8), higher drug content (~79%), greater drug permeation (~70%) and good stability for three months. In vivo skin irritation results indicated the developed formulation is non-irritant. MTT assay indicates dose-dependent effect of FG4 with IC50 of 15.56 μg/mL. Anti-cancer activity assessed in rat models indicates the prominent reduction in tumor burden (volume) by 80% following application of fluorouracil-loaded micellar gel for 1 month. The histopathological study further confirms the activity of developed gel in melanoma skin cancer.
Conclusion
The data observed suggests that the polymeric micelles could be a feasible option for delivering fluorouracil in the treatment of basal-cell carcinoma.
Keywords
Subject
Article metadata
| Title | Formulation, Characterization and in vivo Evaluation of 5-Fluorouracil-Loaded Polymeric Micelles for Non-Melanoma Skin Cancer |
|---|---|
| Authors | Navneet Mehan; Vipin Saini; Kumar Manish; Manoj Goyal; Sheetal Devi; Shinu Pottathil; Shery Jacob; Anroop B Nair |
| Affiliations | M.M. College of Pharmacy, Maharishi Markandeshwar (Deemed to be University), Mullana, Ambala, Haryana, INDIA.; Department of Pharmaceutics, ISF College of Pharmacy, Moga, Punjab, INDIA.; Department of Anesthesia Technology, College of Applied Medical Sciences in Jubail, Imam Abdul Rahman Bin Faisal University, Jubail, SAUDI ARABIA.; Department of Biomedical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, SAUDI ARABIA.; Department of Pharmaceutical Sciences, College of Pharmacy, Gulf Medical University, Ajman, UNITED ARAB EMIRATES.; Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, SAUDI ARABIA. |
| Corresponding author | vipinsaini31@rediffmail.com |
| Journal | Indian Journal of Pharmaceutical Education and Research |
| Volume / Issue | Vol. 59, Issue 2 (2025) |
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