Open access · Peer reviewed · No APCs
Original ArticleInternational Journal of Pharmaceutical InvestigationVol. 11 | Issue 4 | 2021 | pp. 354–357Open access
Anticancer Activity of Elytraria acaulis L. Extracts on Triple Negative Breast Cancer Cell Line
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- 1 Centre for Biotechnology, Institute of Science and Technology, Jawaharlal Nehru Technological University, Hyderabad, Telangana, INDIA.
Published in International Journal of Pharmaceutical Investigation
Correspondence: Lavudi Saida
Centre for Biotechnology, Institute of Science and Technology, Jawaharlal Nehru Technological University, Hyderabad, Telangana, INDIA.
Email: lavudisaida@gmail.com
Copyright: © 2021 Manuscript Technomedia. This is an open access article.
- Published:
- Dec 28, 2021
- Received:
- Jul 3, 2021
- Accepted:
- Sep 17, 2021
How to cite
Bastipati, S. B., Kalyani, C., Tulasi, C. D. S. L. N., & Saida, L. (2021). Anticancer Activity of Elytraria acaulis L. Extracts on Triple Negative Breast Cancer Cell Line. International Journal of Pharmaceutical Investigation, 11(4), 354–357. https://doi.org/10.5530/ijpi.2021.4.63
Abstract
Objectives: In the present study, the anticancer potential of the plant extracts of Elytraria acaulis L. (E. acaulis L.) were investigated on human breast cancer cells (MDAMB-231). Methods: Different organic solvent extracts of E. acaulis L. were prepared using methanol, ethanol, ethyl acetate and hexane. The cytotoxicity of plant extracts were evaluated by MTT assay (-(4, 5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide) against MDA MB-231cells. The apoptosis associated morphological changes were also observed with the help of propidium iodide staining method. Results: Of all the solvent extracts, methanol extract has shown the highest activity and its IC50 concentration was found to be 80.8±2.08 μg/ml. The anticancer drug Cis-diammineplatinum (II) dichloride was considered as a standard. Conclusion: In further the bioactive compound should be isolated from the methanol crude extract, which is responsible for the cytotoxic effects.
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Article metadata
| Title | Anticancer Activity of Elytraria acaulis L. Extracts on Triple Negative Breast Cancer Cell Line |
|---|---|
| Authors | Suresh Babu Bastipati; Chepuri Kalyani; Chidepudi Devi Sri Lalitha Naga Tulasi; Lavudi Saida |
| Affiliations | Centre for Biotechnology, Institute of Science and Technology, Jawaharlal Nehru Technological University, Hyderabad, Telangana, INDIA. |
| Corresponding author | lavudisaida@gmail.com |
| Journal | International Journal of Pharmaceutical Investigation |
| Volume / Issue | Vol. 11, Issue 4 (2021) |
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