The Effect of the Mixture of Natural and Cellulose-Based Polymers on the Physicochemical Properties of Sumatriptan Succinate Mucoadhesive Buccal Patches

Purpose: This study aimed to prepare and evaluate mucoadhesive buccal patches of Sumatriptan Succinate (SUS) made from natural polymers to improve bioavailability, patient compliance, and dose-dependent adverse effects associated with currently available dosage forms. Materials and Methods: The solvent casting method was used with a 32 factorial design. The base polymer was water-soluble polysaccharide pullulan at 2% m/v. NaCMC, SA, PVA, and PVP-K30 was also added in various amounts. The polymer-plasticizer solution, SUS, and SS were combined and dried before being cut into 2 cm patches. The patch was water-resistant-backed and stored at room temperature in an airtight glass jar. Results: The patches had a mass uniformity of 61.75 mg to 84.18 mg and a film thickness of 0.2 mm to 0.5 mm. Some formulations demonstrated excellent folding endurance, with some exceeding 300 folds. The drug content ranged from 6.0 to 9.2 mg, with high drug loading efficiency in formulation SB29 (95%). The patches surface pH ranged from 6.0 to 7.2. At 120 min, formulation SA19 showed significant swelling (70±3%) but achieved maximum drug release (100.2%) in a shorter time. Permeation studies discovered a link between drug release and permeation. Various analyses and accelerated stability tests revealed no significant changes in physicochemical properties. Conclusion: This study demonstrated that the prepared mucoadhesive buccal patches of SUS might be useful in treating migraines, promising improved therapeutic outcomes, increased patient compliance, reduced side effects, and cost benefits.