Recently Isolated Fawcettimine-Type Alkaloids

Since long back, many Lycopodiaceae or Huperziaceae plants species like Lycopodium clavatum L. serratum, Huperzia serrata, H. carinata, Phlegmariurus squarrosus and P. henryi are being traditionally used in treatment of diseases like Alzheimer’s disease and myasthenia gravis. In pursuit of pharmacologically active molecules, here AChE inhibitors present in any of widely used Lycopodiaceae or Huperziaceae plants species, several researchers successfully isolated hundreds of Lycopidium alkaloids, grouped into four classes, one of which is fawcettimine. This review enlisted all fawcettimine alkaloids, isolation and total laboratory synthesis of which have been reported since 2011 (for ex. fawcettimine, lycoflexine, and lycoposerramine B, Lycopoclavamine-A). It can be concluded that, fawcettimine molecule can used as main nucleus which can used as precursor for synthesize new pharmacologically active moieties.