Agmatine as a Promising Neuroprotective Strategy for Treating Neurological Disorders

Agmatine, an endogenous amine with cationic properties, serves as a precursor for polyamine synthesis and has diverse pharmacological effects on the central nervous system. Its neuroprotective mechanisms include preventing brain edema, preserving blood-brain barrier integrity and modulating oxidative stress, inflammation and apoptosis. Despite its promising therapeutic potential, further clinical trials are needed to fully understand its efficacy and safety in neurological conditions. Agmatine has shown promising neuroprotective effects in various neurological disorders, such as ischemic stroke, traumatic brain injury, epilepsy, Parkinson’s disease and Alzheimer’s disease. Clinical evidence supports its efficacy in improving neurological outcomes and cognitive function in patients with ischemic stroke, depression and mild cognitive impairment. This review explores the neuroprotective mechanisms of agmatine and its translational potential in neurological disorders, highlighting its multifaceted actions and potential synergies with existing treatments. The mechanisms underlying agmatine’s neuroprotective actions, its translational implications and potential synergies with existing treatments are discussed.