Formulation and Evaluation of Quercetin Ethosomal Hydrogel for Topical Delivery System

Introduction

Ethosomes are non-invasive drug delivery systems that enable drugs to enter the bloodstream or deep layers of the skin and these are phospholipid-based elastic Nano vesicles with a high ethanol concentration (20-45%). In vesicular systems, ethanol is a well-known permeability enhancer that has been utilized to produce elastic Nano vesicles. Quercetin (QT) is one of the most prevalent polyphenolic flavonoids found in fruits and vegetables, and it has several biological and health-promoting effects in a variety of disorders. The current study sought to formulate ethosomal gel and hydrogel as topical drug delivery.

Materials and Methods

The ethosomes formulations were made by hot method using phospholipid and ethanol (20% to 40%) and then tested for particle size, PDI, percentage entrapment efficiency and Scanning Electron Microscopy (SEM), in vitro drug release study, zeta potential, Then quercetin-loaded ethosomal gel and quercetin hydrogel were prepared and tested for pH, spreadability, viscosity, washability, drug content, visual observation, and extrudability.

Results and Discussion

FT-IR investigations demonstrated that there was no interaction between the medication and the excipients. Compared to regular hydrogel, the results suggested that ethosomal gel might be a useful transdermal delivery system for quercetin in the treatment of inflammation.