Preparation and in vitro Characterization of Diacerein Microsponges Loaded Topical Gels

Background

This study’s objective was to create and assess diacerein-loaded microsponges incorporated into a topical gel formulation for enhanced skin delivery. Diacerein is a potent anti-inflammatory agent used in the management of various dermatological conditions, including osteoarthritis and psoriasis.

Materials and Methods

The optimized diacerein-loaded Additionally, a gel basis was enhanced using microsponges and the resulting topical. The gel’s pH, viscosity, spreadability and homogeneity of drug content were assessed and skin permeation studies. The topical gel’s pH was changed to make sure compatibility with the skin pH for enhanced drug delivery. The prepared diacerein-loaded microsponges incorporated into a topical gel formulation showed promising characteristics for enhanced skin delivery.

Results

Evaluation parameters like viscosity, drug content, spreadability for all the prepared formulations were assessed. Formulation F2 and F4 shows the most optimized result from all the six formulations.

Conclusion

The sustained release pattern achieved through the microsponges technology offers the potential for prolonged therapeutic effects and improved patient outcomes in the treatment of dermatological conditions.