Advancement and in vitro Characterization of an Ocular Gel Containing Chitosomal Encapsulated Drug for Glaucoma Therapy

Background

The most popular and well-designed nano-carriers for drug delivery targeting are liposomes. In order to overcome barriers to cellular and tissue uptake and increase medication bio-distribution to target areas in vivo, they have improved medicines for a variety of biomedical applications.

Objectives

The diffusion method is used to release the medication from liposomes. The major goals of this medication delivery system were to increase contact resistance duration in the eye and bioavailability.

Materials and Methods

Liposomes were effectively produced by reverse phase evaporation technique and their shape, particle size, drug entrapment efficiency and content were examined. Liposomes were prepared by using drug, egg lecithin, chloroform, and diethyl ether.

Results

This dosage form bears considerable promise for drug release, according to in vitro experiments. As a result, the design of the liposomes revealed virtually spherical vesicles. Up to 88.9% and 92.1%, respectively, of the EE% and DC% were possible. Studies on medication release from liposomes in vitro demonstrate that an increase in lipid concentration delays drug release.

Conclusion

The drug is known as dorzolamide in accordance with the conclusions of the investigations stated above. The medicine is stable in all pH, it was found after the Preformulation experiment was over. The dorzolamide curve was calibrated in analytical experiments using phosphate buffers with pH values of 5.6, 7.4 and 6.8. As a result of the inquiry, it was established that the standard plot may be used in additional analytical studies. Liposome batches show that integration efficiency rose with increasing polymer content. The manufactured liposomes’ surface was examined using scanner electron microscopy.