Elevating Therapeutic Potential: Levofloxacin-Loaded Ocular Films for Conjunctivitis Management

Background

The study aimed to develop ocular films containing levofloxacin to treat conjunctivitis. These films were meticulously prepared using a combination of Gelatin, Aloe barbadensis leaves mucilage, and HPMC K4M, by the solvent casting technique, with the primary objective of enhancing the therapeutic efficacy of levofloxacin for this specific eye condition.

Materials and Methods

A comprehensive evaluation was carried out to ensure the quality and reliability of the films, encompassing parameters such as film thickness, weight variation, content uniformity, percentage moisture loss, and absorption capacity. In addition, in vitro drug discharge studies were conducted to simulate the eye’s conditions and understand the controlled discharge of the drug. The study also considered the influence of polymer concentrations, on drug discharge using Design Expert software’s Box Behnken Design.

Results

Notably, the research revealed that the ocular films followed zero-order kinetics, meaning they discharged the drug at a constant rate over time.

Conclusion

Furthermore, the films demonstrated stability under ambient conditions, making them a promising alternative for prolonged drug delivery and improved therapeutic outcomes in conjunctivitis treatment