Synthesis Characterisation in silico Studies and Anti-bacterial Evaluation of Acetaminophen Chalcone Derivatives

Background

Design synthesis of Acetaminophen-chalcone conjugates and finding the in silico studies and characterisation of compounds. Determination of biological activity mainly emphasise on Antibacterial activity. Chalcones are a group of plant-derived polyphenolic compounds that possess a wide variety of biological activities. It acts as precursor of several biosynthetic pathways in the production of flavonoids and isoflavonoids. Chalcones shows activity mainly because of an enone pharmacophore in their structures.

Materials and Methods

Five chalcone derivatives were synthesised by using Claisen Schmidt reaction of appropriate Ketones or substituted Ketones with Benzaldehydes or Substituted Benzaldehydes in presence of Catalyst and Ethanol. The structure of synthesised analogs was determined by its Physico-chemical properties like Solubility, Melting point and thin layer chromatography followed by Spectral analysis IR, 1H NMR. This study provides an overview of an Antibacterial activity of Acetaminophen-Chalcone derivatives. In silico studies were performed on all compounds using Molinspiration, Protox, Swiss ADME softwares. This study aimed to investigate the potential antibacterial activity of Acetaminophen-Chalcone compounds using agar diffusion method.

Results

In this present work we designed five different Chalcone derivatives AS1, AV2, AA3, APC4 and APN5. In silico studies were analysed. Antibacterial activities of derived chalcones were screened for Escheria coli, Staphylococcus aureus, Pseudomonas aeruginosa, Bacillus subtilis.

Conclusion

APN5 drug shows broad spectrum of antibacterial activity against all the four bacterial strain and in all the respective concentrations.