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Original Research ArticleInternational Journal of Pharmaceutical InvestigationVol. 4 | Issue 1 | 2014 | pp. 15–18Open access
Polyethylene glycolated PAMAM dendrimers-Efavirenz conjugates
- 1*,
- 1,
- 2
- 1 Department of Pharmaceutics, Hindu College of Pharmacy, Acharya Nagarjuna University, Guntur, Andhra Pradesh, INDIA.
- 2 School of Pharmacy, University College Sadaya International University, JalanMenara Gading, Kuala Lumpur, MALAYSIA.
Published in International Journal of Pharmaceutical Investigation
Correspondence: Suneela Pyreddy
Department of Pharmaceutics, Hindu College of Pharmacy, Acharya Nagarjuna University, Guntur, Andhra Pradesh, INDIA.
Email: dineshclbaid@gmail.com
Copyright: © 2014 Manuscript Technomedia. This is an open access article.
- Published:
- Feb 21, 2014
How to cite
Pyreddy, S., Kumar, P. D., & Kumar, P. V. (2014). Polyethylene glycolated PAMAM dendrimers-Efavirenz conjugates. International Journal of Pharmaceutical Investigation, 4(1), 15–18. https://doi.org/10.4103/2230-973X.127735
Abstract
Aim: The preparation of novel PEGylated PAMAM (poly-amidoamine) dendrimers for delivery of anti-HIV drug Efavirenz is reported. Method and Materials: About 5.0 G PAMAM dendrimers are prepared by ethylene diamine core via Michael addition by divergent method. PEGylation is done by polyethylene glycol 600 using epichlorhydrin as linker. PEGylated 5.0 G PAMAM dendrimers loaded with Efavirenz (EFV) are evaluated for FTIR, DSC, SEM, drug release, and stability studies. Results and Conclusion: From the results it is proved that this method is less time consuming, inexpensive, and reproducible. Drug-release studies indicate, PEGylated 5.0 G PAMAM-EFV dendrimers have shown prolonged drugrelease property.
Keywords
Subject
Article metadata
| Title | Polyethylene glycolated PAMAM dendrimers-Efavirenz conjugates |
|---|---|
| Authors | Suneela Pyreddy; Pandurangan Dinesh Kumar; Palanirajan Vijayaraj Kumar |
| Affiliations | Department of Pharmaceutics, Hindu College of Pharmacy, Acharya Nagarjuna University, Guntur, Andhra Pradesh, INDIA.; School of Pharmacy, University College Sadaya International University, JalanMenara Gading, Kuala Lumpur, MALAYSIA. |
| Corresponding author | dineshclbaid@gmail.com |
| Journal | International Journal of Pharmaceutical Investigation |
| Volume / Issue | Vol. 4, Issue 1 (2014) |
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