Open access · Peer reviewed · No APCs
Pharm AnalysisJournal of Young PharmacistsVol. 1 | Issue 4 | 2009 | pp. 351–353Open access
A Validated Method for Development of Tenofovir as API and Tablet Dosage Forms by UV Spectroscopy
- 1*,
- 2,
- 3,
- 1,
- 1,
- 1
- 1 Division of Pharmaceutical Sciences, INDIA.
- 2 Department of Chemistry, Shri Guru Ram Rai Institute of Technology and Sciences, Patel Nagar, Dehradun-248001, Uttarakhand, INDIA.
- 3 Department of Pharmacy, Kumoun University, Bhimtal, Nainital, INDIA.
Published in Journal of Young Pharmacists
Correspondence: Gnanarajan G
Division of Pharmaceutical Sciences, INDIA.
Email: rajangnana76@yahoo.com
Copyright: © 2009 Manuscript Technomedia. This is an open access article.
- Published:
- Dec 18, 2009
How to cite
G, G., AK, G., V, J., P, K., PK, Y., & P, K. (2009). A Validated Method for Development of Tenofovir as API and Tablet Dosage Forms by UV Spectroscopy. Journal of Young Pharmacists, 1(4), 351–353. https://doi.org/10.4103/0975-1483.59326
Abstract
A simple new spectrophotometric method has been developed for estimation of Tenofovir disoproxil fumarate in bulk and tablet dosage form. Tenofovir disoproxil fumarate is estimated to be 261 nm in triple distilled water. The Beers law is obeyed in the concentration range of 5 90 µg/mL of the drug. The slope and intercept values are 0.0109 and 0.1075, respectively. Results of analysis of this method have been validated statically and by recovery studies. The method is applied to the marketed tablet formulation. A result of the analysis of tablet formulation, given as a percentage of label claim ± standard deviation is 98.15 ± 0.76. The precision and accuracy has been examined by performing recovery studies and found to be 100.06 ± 1.24. The developed method is simple, sensitive, and reproducible, and can be used for the routine analysis of Tenofovir disoproxil fumarate in bulk and tablet dosage form.
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Article metadata
| Title | A Validated Method for Development of Tenofovir as API and Tablet Dosage Forms by UV Spectroscopy |
|---|---|
| Authors | Gnanarajan G; Gupta AK; Juyal V; Kumar P; Yadav PK; Kailash P |
| Affiliations | Division of Pharmaceutical Sciences, INDIA.; Department of Chemistry, Shri Guru Ram Rai Institute of Technology and Sciences, Patel Nagar, Dehradun-248001, Uttarakhand, INDIA.; Department of Pharmacy, Kumoun University, Bhimtal, Nainital, INDIA. |
| Corresponding author | rajangnana76@yahoo.com |
| Journal | Journal of Young Pharmacists |
| Volume / Issue | Vol. 1, Issue 4 (2009) |
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