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Original ArtcileJournal of Young PharmacistsVol. 13 | Issue 3 | 2021 | pp. 229–234Open access
Assessment of Hepatoprotective and Antioxidant Activities of Ethanolic Extract of Tephrosia villosa in Albino Rats
- 1*,
- 1,
- 2,
- 2
- 1 Department of Pharmacology, CES College of Pharmacy, Kurnool, Andhra Pradesh, INDIA.
- 2 Department of Pharmacology, All India Institute of Medical Sciences, Raipur, Chhattisgarh, INDIA.
Published in Journal of Young Pharmacists
Correspondence: Chakali Ayyanna
Department of Pharmacology, CES College of Pharmacy, Kurnool, Andhra Pradesh, INDIA.
Email: sudhanmcmbbs@gmail.com
Copyright: © 2021 Manuscript Technomedia. This is an open access article.
- Published:
- Sep 22, 2021
- Received:
- Jun 6, 2021
- Accepted:
- Sep 2, 2021
How to cite
Ayyanna, C., Mounika, B., Yella, S. S. T., & Thangaraju, P. (2021). Assessment of Hepatoprotective and Antioxidant Activities of Ethanolic Extract of Tephrosia villosa in Albino Rats. Journal of Young Pharmacists, 13(3), 229–234. https://doi.org/10.5530/jyp.2021.13.47
Abstract
Objectives: To Study the hepatoprotective and antioxidant activity of the whole plant, ethanolic extract of Tephrosia villosa (EETV). Methods: Hepatoprotective effect of EETV is studied against carbon tetrachloride (CCl4 ) and paracetamol-induced hepatotoxicity in rats. Individual rats received EETV doses of 200 and 400 mg/kg (w/w) for seven days, respectively. On the 7th day, induced hepatotoxicity in all rats of all groups by 1.25 ml/kg (i.p) CCl4 and paracetamol 1gm/kg/p.o. Determining effects of ETEV on antioxidant activity, SGOT, SGPT, ALP, and direct bilirubin were, and also performed a histopathological exam of the liver sections. Results: The extract prevented the exhaustion of glutathione and catalase levels and increased lipid peroxidation levels against CCl4 induced and Paracetamol liver injury in rats. By histopathological evidence, EETV also significantly decreased biochemical levels of liver enzymes with high hepatoprotection at 200 mg/kg. Conclusion: Present study results strongly reveal that EETV has hepatoprotective and antioxidant activity against CCl4 and paracetamolinduced hepatic impairment in experimental animals.
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Article metadata
| Title | Assessment of Hepatoprotective and Antioxidant Activities of Ethanolic Extract of Tephrosia villosa in Albino Rats |
|---|---|
| Authors | Chakali Ayyanna; Boyini Mounika; Sree Sudha Tanguturi Yella; Pugazhenthan Thangaraju |
| Affiliations | Department of Pharmacology, CES College of Pharmacy, Kurnool, Andhra Pradesh, INDIA.; Department of Pharmacology, All India Institute of Medical Sciences, Raipur, Chhattisgarh, INDIA. |
| Corresponding author | sudhanmcmbbs@gmail.com |
| Journal | Journal of Young Pharmacists |
| Volume / Issue | Vol. 13, Issue 3 (2021) |
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