Open access · Peer reviewed · No APCs
Review ArticleJournal of Young PharmacistsVol. 18 | Issue 1 | 2026 | pp. 70–79Open access
Graphene-Based Electrochemical Biosensors for Oral Cancer Detection: Advances, Challenges, and Future Prospects-A Systematic Review
- 1,
- 2,
- 3,
- 4,
- 5,
- 6,
- 7,
- 8,
- 9,
- 9,
- 9*
- 1 Department of Pharmacology, Institute of Pharmaceutical Research, GLA University, Mathura, Uttar Pradesh, INDIA.
- 2 Department of Pharmacology, School of Pharmaceutical Sciences, Vels Institute of Science, Technology and Advanced Studies (VISTAS), Pallavaram, Chennai, Tamil Nadu, INDIA.
- 3 Department of Pharmacy Practice, Teerthanker Mahaveer College of Pharmacy, Teerthanker Mahaveer University, Moradabad, Uttar Pradesh, INDIA.
- 4 Department of Pharmaceutical Analysis, Malla Reddy Institute of Pharmaceutical Sciences, Malla Reddy Vishwavidyapeeth (Deemed to be University), Secunderabad, Telangana, INDIA.
- 5 Department of Chemistry, Raffles University, Neemrana, Alwar, Rajasthan, INDIA.
- 6 Department of Chemistry, School of Basic and Applied Sciences, Raffles University, Neemrana, Rajasthan, INDIA.
- 7 Koneru Lakshmaiah Education Foundation, Green Fields, Vaddeswaram, Andhra Pradesh, INDIA.
- 8 Department of Pharmacology and Pharmacokinetics, Quest Life Sciences Pvt. Ltd., Research Foundation in Chennai, Chennai, Tamil Nadu, INDIA.
- 9 Department of Pharmacology, Saveetha College of Pharmacy, Saveetha Institute of Medical and Technical Sciences (SIMATS), Thandalam, Saveetha Nagar, Thandalam, Chennai, Tamil Nadu, INDIA.
Published in Journal of Young Pharmacists
Correspondence: Lokeshvar Ravikumar
Department of Pharmacology, Saveetha College of Pharmacy, Saveetha Institute of Medical and Technical Sciences (SIMATS), Thandalam, Saveetha Nagar, Thandalam, Chennai, Tamil Nadu, INDIA.
Email: lokeshvarr.scop@saveetha.com
Copyright: © 2026 Manuscript Technomedia. This is an open access article.
- Published:
- Mar 25, 2026
- Received:
- Nov 3, 2025
- Accepted:
- Feb 16, 2026
- DOI:
- 10.5530/jyp.20260170
How to cite
Gupta, J. K., Jaganath, P., Babu, R. H., Reddy, K. T. K., Dantinapalli, V. L. S., Elumalai, S., Yadav, T. C., Rachumallu, V. R., Sankar, P., Srinivasan, J. S., & Ravikumar, L. (2026). Graphene-Based Electrochemical Biosensors for Oral Cancer Detection: Advances, Challenges, and Future Prospects-A Systematic Review. Journal of Young Pharmacists, 18(1), 70–79. https://doi.org/10.5530/jyp.20260170
Abstract
Graphene-based electrochemical biosensors are emerging as powerful diagnostic platforms for early, non-invasive detection of oral cancer. This review critically evaluates recent advances in graphene-enabled salivary biosensing, emphasizing the role of graphene’s unique physicochemical properties-such as large surface area, conductivity, and biocompatibility-in improving sensitivity and specificity. A comprehensive literature search was conducted using PubMed, Scopus, and ScienceDirect databases to identify peer-reviewed studies from 2010-2025 on graphene-based electrochemical biosensors for salivary biomarker detection. The findings indicate that graphene-integrated systems significantly enhance electrochemical detection techniques including voltammetry, impedance spectroscopy, and field-effect transistors. Major challenges remain in clinical translation, including reproducibility, scalability, and regulatory approval. Future perspectives involve integrating these biosensors with artificial intelligence, microfluidics, and telemedicine platforms to enable affordable, portable, and real-time oral cancer diagnostics. Overall, graphene-based biosensors represent a transformative step toward personalized, point-of-care cancer management.
Keywords
Subject
Article metadata
| Title | Graphene-Based Electrochemical Biosensors for Oral Cancer Detection: Advances, Challenges, and Future Prospects-A Systematic Review |
|---|---|
| Authors | Jeetendra Kumar Gupta; Priyanga Jaganath; Ramenani Hari Babu; Konatham Teja Kumar Reddy; Venkata Lakshamana Sagar Dantinapalli; Selvaraja Elumalai; Thota Chandrasekhar Yadav; Venkateswara Rao Rachumallu; Prabakaran Sankar; Jaya Shree Srinivasan; Lokeshvar Ravikumar |
| Affiliations | Department of Pharmacology, Institute of Pharmaceutical Research, GLA University, Mathura, Uttar Pradesh, INDIA.; Department of Pharmacology, School of Pharmaceutical Sciences, Vels Institute of Science, Technology and Advanced Studies (VISTAS), Pallavaram, Chennai, Tamil Nadu, INDIA.; Department of Pharmacy Practice, Teerthanker Mahaveer College of Pharmacy, Teerthanker Mahaveer University, Moradabad, Uttar Pradesh, INDIA.; Department of Pharmaceutical Analysis, Malla Reddy Institute of Pharmaceutical Sciences, Malla Reddy Vishwavidyapeeth (Deemed to be University), Secunderabad, Telangana, INDIA.; Department of Chemistry, Raffles University, Neemrana, Alwar, Rajasthan, INDIA.; Department of Chemistry, School of Basic and Applied Sciences, Raffles University, Neemrana, Rajasthan, INDIA.; Koneru Lakshmaiah Education Foundation, Green Fields, Vaddeswaram, Andhra Pradesh, INDIA.; Department of Pharmacology and Pharmacokinetics, Quest Life Sciences Pvt. Ltd., Research Foundation in Chennai, Chennai, Tamil Nadu, INDIA.; Department of Pharmacology, Saveetha College of Pharmacy, Saveetha Institute of Medical and Technical Sciences (SIMATS), Thandalam, Saveetha Nagar, Thandalam, Chennai, Tamil Nadu, INDIA. |
| Corresponding author | lokeshvarr.scop@saveetha.com |
| Journal | Journal of Young Pharmacists |
| Volume / Issue | Vol. 18, Issue 1 (2026) |
Also in this issue
- Pathogenesis, Molecular Mechanism, Targets and Treatment Strategies to Accelerate Diabetic Wound Healingpp. 1–16
- Next-Generation Oncolytics Viruses: Smart, Immune-Driven Cancer Destroyerspp. 17–22
- Trigonelline and Cardiovascular Health: A Narrative Review of Mechanisms, Preclinical Evidence, and Translational Considerationspp. 23–27
- Hesperidin: A Comprehensive Review of its Pharmacological Activities and Therapeutic Applicationspp. 28–38
- Fruit Flies: From Model Organism to Medical Marvel in Pharmaceutical Researchpp. 39–45
Readers Also Viewed
Development and Validation of UV/visible Spectrophotometric Method for Estimation of Piroxicam from Bulk and Formulation
Sandip Mohan Honmane, Kunal Rajaram Yadav, Yuvraj Dilip Dange
Apr 23, 2025
Effects of Artificial Intelligence on Academic Performance of Library and Information Science University Students: A Meta-Analysis (2023-2025)
Kayode Sunday John Dada
Aug 6, 2026
Bridging Innovation and Impact: A Multidisciplinary Approach to Contemporary Research Challenges
Mueen Ahmed KK
Aug 11, 2026