Open access · Peer reviewed · No APCs
Quality AssuranceJournal of Young PharmacistsVol. 2 | Issue 1 | 2010 | pp. 79–85Open access
Stability Indicating High-Performance Liquid Chromatography Method for the Estimation of Artemether in Capsule Dosage Forms
- 1*,
- 2,
- 2
- 1 Department of Pharm. Sciences, B.R. Nahata College of Pharmacy, Mhow-Neemuch Road, Mandsaur, Madhya Pradesh, INDIA.
- 2 L.M. College of Science and Technology, Pharmacy wing, Shastri Nagar, Sector A, Jodhpur, Rajasthan, INDIA.
Published in Journal of Young Pharmacists
Correspondence: Shrivastava A
Department of Pharm. Sciences, B.R. Nahata College of Pharmacy, Mhow-Neemuch Road, Mandsaur, Madhya Pradesh, INDIA.
Email: alankarshrivastava@gmail.com
Copyright: © 2010 Manuscript Technomedia. This is an open access article.
- Published:
- Jan 10, 2010
How to cite
A, S., R, I., & BP, N. (2010). Stability Indicating High-Performance Liquid Chromatography Method for the Estimation of Artemether in Capsule Dosage Forms. Journal of Young Pharmacists, 2(1), 79–85. https://doi.org/10.4103/0975-1483.62220
Abstract
A new simple, sensitive, precise, and accurate high-performance liquid chromatography (HPLC) method of analysis for artemether both as a bulk drug and in capsule formulations was developed and validated. The method employed mobile phase acetonitrile (ACN) and buffer in the ratio 65:35 of pH 6.5 adjusted with tryethylamine. The linear regression analysis data for the calibration plots showed good linear relationship with r2 5 0.9996 in the concentration range 250-750 mg/ml. The mean value slope and intercept were 9355.5 and 293.5, respectively. The method was validated for precision, accuracy, and recovery studies. Limit of detection (LOD) and Limit of quantitation (LOQ) for artemether were found to be 21.83-750 mg/ml, respectively. The method has been successfully applied in the analysis of marketed capsule formulations. The presented method was found to be reliable to separate all the degradents from all the stress conditions with resolution of more than 1.5 showing that it is a stability indicating method.
Keywords
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Article metadata
| Title | Stability Indicating High-Performance Liquid Chromatography Method for the Estimation of Artemether in Capsule Dosage Forms |
|---|---|
| Authors | Shrivastava A; Issarani R; Nagori BP |
| Affiliations | Department of Pharm. Sciences, B.R. Nahata College of Pharmacy, Mhow-Neemuch Road, Mandsaur, Madhya Pradesh, INDIA.; L.M. College of Science and Technology, Pharmacy wing, Shastri Nagar, Sector A, Jodhpur, Rajasthan, INDIA. |
| Corresponding author | alankarshrivastava@gmail.com |
| Journal | Journal of Young Pharmacists |
| Volume / Issue | Vol. 2, Issue 1 (2010) |
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