Open access · Peer reviewed · No APCs
PharmacognosyJournal of Young PharmacistsVol. 2 | Issue 2 | 2010 | pp. 130–136Open access
Aqueous Extract of Ficus bengalensis Linn. Bark for Inflammatory Bowel Disease
- 1*,
- 1,
- 2
- 1 Department of Pharmacology, C. K. Pithawala Institute of Pharmaceutical Sciences and Research, Surat-395007, Gujarat, INDIA.
- 2 Department of Pharmacology, Shri Sarvajanik College of Pharmacy, Mahesana, Gujarat, INDIA.
Published in Journal of Young Pharmacists
Correspondence: Patel MA
Department of Pharmacology, C. K. Pithawala Institute of Pharmaceutical Sciences and Research, Surat-395007, Gujarat, INDIA.
Email: hdpharmacology@gmail.com
Copyright: © 2010 Manuscript Technomedia. This is an open access article.
- Published:
- Apr 22, 2010
How to cite
MA, P., PK, P., & MB, P. (2010). Aqueous Extract of Ficus bengalensis Linn. Bark for Inflammatory Bowel Disease. Journal of Young Pharmacists, 2(2), 130–136. https://doi.org/10.4103/0975-1483.63149
Abstract
The present study was designed to evaluate the effects of aqueous extract of Ficus bengalensis Linn. bark (AEFB) on inflammatory bowel disease (IBD). Effects of AEFB were studied on 2, 4, 6-trinitrobenzenesulfonic acid (TNBS, 0.25 ml 120 mg/ml in 50% ethanol intrarectally, on first day only)-induced IBD in rats. Effects of coadministration of prednisolone (2 mg/kg) and AEFB (250, 500 mg/kg) for 21 days were also evaluated. Various physical parameters including body weight, food, and water intake measured on 1st and 21st days. At end of the experiment, various histopathological indexes are assessed. The colon homogenate malondialdehyde (MDA), myeloperoxidase (MPO), superoxide dismutase (SOD), and nitric oxide (NO) levels and % mast cell protection in mesentery were also measured. In our study, we found that AEFB has a significant protective effect in the inflammatory bowel disease as compared to prednisolone in rats.
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Article metadata
| Title | Aqueous Extract of Ficus bengalensis Linn. Bark for Inflammatory Bowel Disease |
|---|---|
| Authors | Patel MA; Patel PK; Patel MB |
| Affiliations | Department of Pharmacology, C. K. Pithawala Institute of Pharmaceutical Sciences and Research, Surat-395007, Gujarat, INDIA.; Department of Pharmacology, Shri Sarvajanik College of Pharmacy, Mahesana, Gujarat, INDIA. |
| Corresponding author | hdpharmacology@gmail.com |
| Journal | Journal of Young Pharmacists |
| Volume / Issue | Vol. 2, Issue 2 (2010) |
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