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PharmacologyJournal of Young PharmacistsVol. 2 | Issue 4 | 2010 | pp. 384–387Open access
Evaluation of the Hypoglycemic Activity of Cucumis metuliferus (Cucurbitaceae) Fruit Pulp Extract in Normoglycemic and Alloxan- Induced Hyperglycemic Rats
- 1*,
- 2,
- 1,
- 2
- 1 Departments of Clinical Pharmacy, NIGERIA.
- 2 Pharmacology, Faculty of Pharmaceutical Sciences, University of Jos, Jos, NIGERIA.
Published in Journal of Young Pharmacists
Correspondence: Jimam NS
Departments of Clinical Pharmacy, NIGERIA.
Email: jimams@unijos.edu.ng
Copyright: © 2010 Manuscript Technomedia. This is an open access article.
- Published:
- Oct 15, 2010
How to cite
NS, J., NN, W., S, O., & B, G. (2010). Evaluation of the Hypoglycemic Activity of Cucumis metuliferus (Cucurbitaceae) Fruit Pulp Extract in Normoglycemic and Alloxan- Induced Hyperglycemic Rats. Journal of Young Pharmacists, 2(4), 384–387. https://doi.org/10.4103/0975-1483.71633
Abstract
The hypoglycemic effects of the fruit extract of C. metuliferus was investigated in normoglycemic and alloxaninduced hyperglycemic rats. The results showed that there was an insignificant (P > 0.05) decrease in the blood glucose concentration of normoglycemic rats treated with oral doses of 1000 and 1500 mg/kg of the extract. On the other hand, 500 mg/kg of the fruit extract produced an insignificant (P > 0.05) decrease in blood glucose levels of alloxan-treated rats, while 1000 and 1500 mg/kg oral dose points produced a significant (P < 0.05) decrease in the blood glucose concentration of hyperglycemic rats comparable to that produced by tolbutamide. From this study, the data suggested that the fruit extract did not alter the BGC level in normoglycemic rats, but had a potential hypoglycemic property in alloxan-induced hyperglycemic rats.
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Article metadata
| Title | Evaluation of the Hypoglycemic Activity of Cucumis metuliferus (Cucurbitaceae) Fruit Pulp Extract in Normoglycemic and Alloxan- Induced Hyperglycemic Rats |
|---|---|
| Authors | Jimam NS; Wannang NN; Omale S; Gotom B |
| Affiliations | Departments of Clinical Pharmacy, NIGERIA.; Pharmacology, Faculty of Pharmaceutical Sciences, University of Jos, Jos, NIGERIA. |
| Corresponding author | jimams@unijos.edu.ng |
| Journal | Journal of Young Pharmacists |
| Volume / Issue | Vol. 2, Issue 4 (2010) |
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