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PharmacologyJournal of Young PharmacistsVol. 3 | Issue 4 | 2011 | pp. 297–303Open access
Cardioprotective Effects of Lagenaria siceraria Fruit Juice on Isoproterenol-induced Myocardial Infarction in Wistar Rats: A Biochemical and Histoarchitecture Study
- 1*,
- 1
- 1 Pharmacy Department, Faculty of Technology and Engineering, The M. S. University of Baroda, Vadodara, Gujarat, INDIA.
Published in Journal of Young Pharmacists
Correspondence: Upaganlawar A
Pharmacy Department, Faculty of Technology and Engineering, The M. S. University of Baroda, Vadodara, Gujarat, INDIA.
Email: amanrx@yahoo.com
Copyright: © 2011 Manuscript Technomedia. This is an open access article.
- Published:
- Nov 22, 2011
How to cite
A, U., & R, B. (2011). Cardioprotective Effects of Lagenaria siceraria Fruit Juice on Isoproterenol-induced Myocardial Infarction in Wistar Rats: A Biochemical and Histoarchitecture Study. Journal of Young Pharmacists, 3(4), 297–303. https://doi.org/10.4103/0975-1483.90241
Abstract
The present study was designed to evaluate the cardioprotective effects of Lagenaria siceraria fruit juice in isoproterenol-induced myocardial infarction. Rats injected with isoproterenol (200 mg/kg, s.c.) showed a significant increase in the levels of serum uric acid, tissue Na and Ca** ions and membrane-bound Ca
and mg*2
-ATPase activity. A significant decrease in the levels of serum protein, tissue K ion, vitamin E level, and the activities of Na+/K+-ATPase and mg*2-ATPase was observed. Isoproterenol injected rats also showed a significant increase in the intensity of lactate dehydrogenase isoenzyme and histopathologic alterations in the heart. Treatment with L. siceraria fruit juice (400 mg/kg/day, p.o.) for 30 days and administration of isoproterenol on 29th and 30th days showed a protective effect on altered biochemical and histopathologic changes. These findings indicate the cardioprotective effect of L. siceraria fruit juice in isoproterenol-induced myocardial infarction in rats.Keywords
Subject
Article metadata
| Title | Cardioprotective Effects of Lagenaria siceraria Fruit Juice on Isoproterenol-induced Myocardial Infarction in Wistar Rats: A Biochemical and Histoarchitecture Study |
|---|---|
| Authors | Upaganlawar A; Balaraman R |
| Affiliations | Pharmacy Department, Faculty of Technology and Engineering, The M. S. University of Baroda, Vadodara, Gujarat, INDIA. |
| Corresponding author | amanrx@yahoo.com |
| Journal | Journal of Young Pharmacists |
| Volume / Issue | Vol. 3, Issue 4 (2011) |
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