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Pharmaceutical ChemistryJournal of Young PharmacistsVol. 3 | Issue 4 | 2011 | pp. 310–314Open access
Synthesis, Characterization and Biological Activity Studies of 1,3,4-Oxadiazole Analogs
- 1*,
- 1,
- 1
- 1 Department of Pharmaceutical Chemistry, NGSM Institute of Pharmaceutical Sciences, Nitte University, Deralakatte, Mangalore, Karnataka, INDIA.
Published in Journal of Young Pharmacists
Correspondence: Bhat KI
Department of Pharmaceutical Chemistry, NGSM Institute of Pharmaceutical Sciences, Nitte University, Deralakatte, Mangalore, Karnataka, INDIA.
Email: bhatishwar@yahoo.co.in
Copyright: © 2011 Manuscript Technomedia. This is an open access article.
- Published:
- Nov 22, 2011
How to cite
KI, B., K, S., & P, C. S. K. (2011). Synthesis, Characterization and Biological Activity Studies of 1,3,4-Oxadiazole Analogs. Journal of Young Pharmacists, 3(4), 310–314. https://doi.org/10.4103/0975-1483.90243
Abstract
The reaction of p-bromoanilino acetohydrazide(II) with aromatic aldehydes in alcohol yielded 2-[4-bromo aniline] N-substituted benzylidine hydrazides (IIIa-IIIj), which in presence of yellow mercuric oxide and iodine in DMF, yielded corresponding 4-bromo[(N-5-substituted 1,3,4 oxadiazole-2-yl)methyl]aniline (IVa-IVj). Structures of the compounds synthesized were confirmed by IR, ^1HNMR and MASS spectroscopic analysis. The newly synthesized compounds were screened for antibacterial, antifungal and anti-inflammatory activities. Some of the compounds showed remarkable antibacterial, antifungal and anti-inflammatory activities.
Keywords
Subject
Article metadata
| Title | Synthesis, Characterization and Biological Activity Studies of 1,3,4-Oxadiazole Analogs |
|---|---|
| Authors | Bhat KI; Sufeera K; Chaitanya Sunil Kumar P |
| Affiliations | Department of Pharmaceutical Chemistry, NGSM Institute of Pharmaceutical Sciences, Nitte University, Deralakatte, Mangalore, Karnataka, INDIA. |
| Corresponding author | bhatishwar@yahoo.co.in |
| Journal | Journal of Young Pharmacists |
| Volume / Issue | Vol. 3, Issue 4 (2011) |
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